Preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation

Corina Danciu, Codruta Soica, Cristina Dehelean, I. Zupkó, Erzsebet Csanyi, Iulia Pinzaru

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.

Original languageEnglish
Article number262930
JournalAnalytical Cellular Pathology
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Genistein
Esterification
Cyclodextrins
Cell Line
Myristic Acid
Fourier Transform Infrared Spectroscopy
Cervix Uteri
Squamous Cell Carcinoma
Ovary
Esters
Adenocarcinoma
Carcinoma
Skin
In Vitro Techniques
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation. / Danciu, Corina; Soica, Codruta; Dehelean, Cristina; Zupkó, I.; Csanyi, Erzsebet; Pinzaru, Iulia.

In: Analytical Cellular Pathology, Vol. 2015, 262930, 2015.

Research output: Contribution to journalArticle

Danciu, Corina ; Soica, Codruta ; Dehelean, Cristina ; Zupkó, I. ; Csanyi, Erzsebet ; Pinzaru, Iulia. / Preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation. In: Analytical Cellular Pathology. 2015 ; Vol. 2015.
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