During the last few years regional colorectal cancer (CRC) screening programs have been performed in Hungary; one of these was organized by the authors in 1995. Fecal occult blood testing (FOBT) followed by colonoscopy in positive cases was chosen as the screening strategy. Of the 7656 individuals (age 50-75) screened with FOBT, 225 (3.7%) were found to be positive. Colonoscopy was performed in 125 cases (compliance 55.5%). Screening identified 18 CRC patients; 14.4% of FOBT-positive patients and 0.2% of all screened individuals proved to have CRC. A total of 49 colorectal polyps were found and were removed in 31 (24.8%) patients. In seven polyp patients the histology showed adenoma with severe dysplasia. Seven years after the initiation of the CRC screening survey the authors searched for previous cancer patients who were detected by screening in 1995. Five Duke's C and B CRC patients (28%) died during the 7 year follow-up but all Duke's A advanced CRC patients were alive. The 7 year follow-up results indicate that the mortality among CRC patients detected by the screening program was lower than the average rate in CRC disease. Based on the recommendation of the Hungarian Society of Gastroenterology, a national CRC screening program is planned using FOBT followed by colonoscopy in positive cases. According to model calculations a need for 60-80,000 colonoscopies per year can be estimated for the entire national screening program.
- Colorectal cancer
ASJC Scopus subject areas