Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats

Stéphane Tanguy, Sandrine Morel, Corinne Berthonneche, Marie Claire Toufektsian, Michel De Lorgeril, Véronique Ducros, A. Tósaki, Joel De Leiris, François Boucher

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium intake affects myocardial necrosis induced by transient regional ischemia in vivo in rats. For this purpose, male Wistar rats received either a high-selenium (High-Se: 1.5 mg of Se/kg) or a low-selenium (Low-Se: 0.05 mg of Se/kg) diet for 10 weeks. Animals were subjected to 30 min of myocardial ischemia induced by coronary artery ligation followed by 60 min of reperfusion. Pre- and postischemic blood samples were collected for glutathione (GSH and GSSG) determination and for glutathione peroxidase (GSH-Px) assessment. Our results show that high-selenium intake reduces myocardial infarct size (High-Se: 25.16 ± 1.19% versus Low-Se: 36.51 ± 4.14%, p <0.05), preserves postischemic GSH/GSSG ratio (High-Se: 1.37 ± 0.37 versus Low-Se: 0.47 ± 0.10, p <0.05), increases plasma GSH-Px activity, and improves postischemic mean arterial pressure. In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status.

Original languageEnglish
Pages (from-to)792-796
Number of pages5
JournalAntioxidants and Redox Signaling
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Selenium
Rats
Myocardial Infarction
Glutathione Disulfide
Myocardial Ischemia
Pathology
Nutrition
Glutathione Peroxidase
Reperfusion
Oxidation-Reduction
Glutathione
Ligation
Wistar Rats
Epidemiologic Studies
Coronary Vessels
Arterial Pressure
Animals
Blood
Necrosis
Ischemia

ASJC Scopus subject areas

  • Biochemistry

Cite this

Tanguy, S., Morel, S., Berthonneche, C., Toufektsian, M. C., De Lorgeril, M., Ducros, V., ... Boucher, F. (2004). Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats. Antioxidants and Redox Signaling, 6(4), 792-796. https://doi.org/10.1089/1523086041361631

Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats. / Tanguy, Stéphane; Morel, Sandrine; Berthonneche, Corinne; Toufektsian, Marie Claire; De Lorgeril, Michel; Ducros, Véronique; Tósaki, A.; De Leiris, Joel; Boucher, François.

In: Antioxidants and Redox Signaling, Vol. 6, No. 4, 08.2004, p. 792-796.

Research output: Contribution to journalArticle

Tanguy, S, Morel, S, Berthonneche, C, Toufektsian, MC, De Lorgeril, M, Ducros, V, Tósaki, A, De Leiris, J & Boucher, F 2004, 'Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats', Antioxidants and Redox Signaling, vol. 6, no. 4, pp. 792-796. https://doi.org/10.1089/1523086041361631
Tanguy, Stéphane ; Morel, Sandrine ; Berthonneche, Corinne ; Toufektsian, Marie Claire ; De Lorgeril, Michel ; Ducros, Véronique ; Tósaki, A. ; De Leiris, Joel ; Boucher, François. / Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats. In: Antioxidants and Redox Signaling. 2004 ; Vol. 6, No. 4. pp. 792-796.
@article{928a4c9b27334749869a375b84b3c8b7,
title = "Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats",
abstract = "Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium intake affects myocardial necrosis induced by transient regional ischemia in vivo in rats. For this purpose, male Wistar rats received either a high-selenium (High-Se: 1.5 mg of Se/kg) or a low-selenium (Low-Se: 0.05 mg of Se/kg) diet for 10 weeks. Animals were subjected to 30 min of myocardial ischemia induced by coronary artery ligation followed by 60 min of reperfusion. Pre- and postischemic blood samples were collected for glutathione (GSH and GSSG) determination and for glutathione peroxidase (GSH-Px) assessment. Our results show that high-selenium intake reduces myocardial infarct size (High-Se: 25.16 ± 1.19{\%} versus Low-Se: 36.51 ± 4.14{\%}, p <0.05), preserves postischemic GSH/GSSG ratio (High-Se: 1.37 ± 0.37 versus Low-Se: 0.47 ± 0.10, p <0.05), increases plasma GSH-Px activity, and improves postischemic mean arterial pressure. In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status.",
author = "St{\'e}phane Tanguy and Sandrine Morel and Corinne Berthonneche and Toufektsian, {Marie Claire} and {De Lorgeril}, Michel and V{\'e}ronique Ducros and A. T{\'o}saki and {De Leiris}, Joel and Fran{\cc}ois Boucher",
year = "2004",
month = "8",
doi = "10.1089/1523086041361631",
language = "English",
volume = "6",
pages = "792--796",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats

AU - Tanguy, Stéphane

AU - Morel, Sandrine

AU - Berthonneche, Corinne

AU - Toufektsian, Marie Claire

AU - De Lorgeril, Michel

AU - Ducros, Véronique

AU - Tósaki, A.

AU - De Leiris, Joel

AU - Boucher, François

PY - 2004/8

Y1 - 2004/8

N2 - Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium intake affects myocardial necrosis induced by transient regional ischemia in vivo in rats. For this purpose, male Wistar rats received either a high-selenium (High-Se: 1.5 mg of Se/kg) or a low-selenium (Low-Se: 0.05 mg of Se/kg) diet for 10 weeks. Animals were subjected to 30 min of myocardial ischemia induced by coronary artery ligation followed by 60 min of reperfusion. Pre- and postischemic blood samples were collected for glutathione (GSH and GSSG) determination and for glutathione peroxidase (GSH-Px) assessment. Our results show that high-selenium intake reduces myocardial infarct size (High-Se: 25.16 ± 1.19% versus Low-Se: 36.51 ± 4.14%, p <0.05), preserves postischemic GSH/GSSG ratio (High-Se: 1.37 ± 0.37 versus Low-Se: 0.47 ± 0.10, p <0.05), increases plasma GSH-Px activity, and improves postischemic mean arterial pressure. In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status.

AB - Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium intake affects myocardial necrosis induced by transient regional ischemia in vivo in rats. For this purpose, male Wistar rats received either a high-selenium (High-Se: 1.5 mg of Se/kg) or a low-selenium (Low-Se: 0.05 mg of Se/kg) diet for 10 weeks. Animals were subjected to 30 min of myocardial ischemia induced by coronary artery ligation followed by 60 min of reperfusion. Pre- and postischemic blood samples were collected for glutathione (GSH and GSSG) determination and for glutathione peroxidase (GSH-Px) assessment. Our results show that high-selenium intake reduces myocardial infarct size (High-Se: 25.16 ± 1.19% versus Low-Se: 36.51 ± 4.14%, p <0.05), preserves postischemic GSH/GSSG ratio (High-Se: 1.37 ± 0.37 versus Low-Se: 0.47 ± 0.10, p <0.05), increases plasma GSH-Px activity, and improves postischemic mean arterial pressure. In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status.

UR - http://www.scopus.com/inward/record.url?scp=3042821935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042821935&partnerID=8YFLogxK

U2 - 10.1089/1523086041361631

DO - 10.1089/1523086041361631

M3 - Article

VL - 6

SP - 792

EP - 796

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 4

ER -