Pregnancy rates with recombinant versus urinary human chorionic gonadotropin in in vitro fertilization: An observational study

József Zeke, Katalin Kanyó, Helga Zeke, Áron Cseh, Barna Vásárhelyi, András Szilágyi, János Konc

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Randomized clinical trials (RCTs) demonstrated the equal efficacy of urinary human chorionic gonadotropin (uhCG) and recombinant hCG (rhCG) products in in vitro fertilisation (IVF). However, limitations inherent with RCTs necessitate the reinforcement of RCT results in real-life. We retrospectively analyzed pregnancies after treatment with rhCG and uhCG products (n = 391, and 96, resp.). We found that laboratory-verified pregnancy occurred more frequently in rhCG patients than in those on uhCG (43 versus 30, P = 0.02). The association remains significant (P = 0.002) after its adjustment for clinical characteristics. The prevalence of laboratory-verified pregnancies was higher with GnRH agonist use (P = 0.012) and BMI under 30kg/m2 (P = 0.053) while decreased the age (P = 0.014) and the number of previous failed attempts (P = 0.08). Similar (but not significant) trends were observed with rates of pregnancy filled the 24th week. These results reinforce RCTs supporting the notion that rhCG is more efficient as uhCG during IVF.

Original languageEnglish
Pages (from-to)1781-1787
Number of pages7
JournalTheScientificWorldJournal
Volume11
DOIs
Publication statusPublished - Nov 23 2011

Keywords

  • assisted reproduction
  • laboratory-verified pregnancy
  • recombinant hCG
  • urinary hCG

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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