Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation - Final report

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

The effect of periconceptional multivitamin/trace element supplementation on pregnancy outcomes was evaluated in a randomised controlled trial. The final data-base included 5,502 females with confirmed pregnancy. A multivitamin including 0.8 mg folic acid or a trace element were supplemented for at least 28 days before conception and continuing for at least until the second missed menstrual period. Number of pregnancies, terminations of pregnancies, four types of fetal deaths, livebirths including low birth weight, preterm birth and sex ratio were analysed. Periconceptional multivitamin supplementation increased fertility (higher rates of cumulative conceptions and multiple births), had no significant effect on the rate of different groups of fetal deaths, low birth weight and preterm birth in singletons. This primary preventive method can reduce the occurrence and recurrence of neural-tube defects and had no other significant effect on pregnancy outcomes except multiple births.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalArchives of Gynecology and Obstetrics
Volume255
Issue number3
DOIs
Publication statusPublished - Jul 1 1994

Keywords

  • Fetal death
  • Folic acid
  • Low birth weight
  • Periconceptional multivitamin supplementation
  • Preterm birth

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation - Final report'. Together they form a unique fingerprint.

  • Cite this