Pregnancy-induced alterations of GABAA receptor sensitivity in maternal brain: an antecedent of post-partum 'blues'?

Maria Dorota Majewska, Felicia Ford-Rice, George Falkay

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Pregnancy increases affinity of [3H]muscimol binding to GABAA receptors in the rat forebrain. Post-partum, the receptor affinity is further increased concomitantly with a reduction of the receptor density. These changes may result from an action of endogenous placental and adrenal steroids, tetrahydroprogesterone and tetrahydrodeoxycorticosterone, which in vitro behave as allosteric agonists of GABAA receptors. The alterations may contribute to the psycholigical phenomena associated with pregnancy and the puerperium.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalBrain research
Volume482
Issue number2
DOIs
Publication statusPublished - Mar 20 1989

Keywords

  • GABA receptor
  • Post-partum blues
  • Pregnancy
  • Steroid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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