Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden

I. Pabinger, L. Nemes, C. Rintelen, S. Koder, E. Lechler, R. M. Loreth, P. A. Kyrle, I. Scharrer, G. Sas, K. Lechner, C. Mannhalter, S. Ehrenforth

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Introduction: To evaluate the pregnancy-associated risk of venous thromboembolism and the risk of stillbirth and miscarriage a multicenter, retrospective and controlled study was conducted in women carrying the homozygous factor V Leiden mutation and in an age-matched control group of women from the normal population. Patients and methods: In 64 homozygous (median age 44 years, range 21-75 years) and in 52 control women from five different centers data on venous thromboembolism and pregnancy outcome were obtained. Results: The 64 homozygous women had in total 212 pregnancies, the 52 control women had 118 pregnancies. In homozygous women 65% of pregnancies ended with delivery of a viable infant, 15% with fetal loss (3.3% stillbirth, 12% miscarriage) and 20% by pregnancy termination. In the control women 75% of pregnancies ended with delivery of a viable infant, 12% with fetal loss (1.7% stillbirth, 10% miscarriage) and 13% by pregnancy termination. The differences were statistically not significant. Venous thromboembolism occurred significantly more often in the homozygous women, in 4.2% (9/212) during pregnancy and in 4.7% (10/212) after delivery or pregnancy termination. None of the control women had a thromboembolic episode. Conclusion: Our data indicate that women with homozygous factor V Leiden have a high probability for a favorable pregnancy outcome. The increased risk for venous thromboembolism during pregnancy and after delivery would favor heparin prophylaxis during and after pregnancy in women homozygous for factor V Leiden.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalHematology Journal
Volume1
Issue number1
Publication statusPublished - 2000

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Venous Thromboembolism
Pregnancy Outcome
Pregnancy
Stillbirth
Spontaneous Abortion
factor V Leiden
Heparin
Research Design
Retrospective Studies
Control Groups
Mutation

Keywords

  • APC resistance
  • Factor V Leiden
  • Pregnancy
  • Thrombophilia
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Cite this

Pabinger, I., Nemes, L., Rintelen, C., Koder, S., Lechler, E., Loreth, R. M., ... Ehrenforth, S. (2000). Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden. Hematology Journal, 1(1), 37-41.

Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden. / Pabinger, I.; Nemes, L.; Rintelen, C.; Koder, S.; Lechler, E.; Loreth, R. M.; Kyrle, P. A.; Scharrer, I.; Sas, G.; Lechner, K.; Mannhalter, C.; Ehrenforth, S.

In: Hematology Journal, Vol. 1, No. 1, 2000, p. 37-41.

Research output: Contribution to journalArticle

Pabinger, I, Nemes, L, Rintelen, C, Koder, S, Lechler, E, Loreth, RM, Kyrle, PA, Scharrer, I, Sas, G, Lechner, K, Mannhalter, C & Ehrenforth, S 2000, 'Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden', Hematology Journal, vol. 1, no. 1, pp. 37-41.
Pabinger, I. ; Nemes, L. ; Rintelen, C. ; Koder, S. ; Lechler, E. ; Loreth, R. M. ; Kyrle, P. A. ; Scharrer, I. ; Sas, G. ; Lechner, K. ; Mannhalter, C. ; Ehrenforth, S. / Pregnancy-associated risk for venous thromboembolism and pregnancy outcome in women homozygous for factor V Leiden. In: Hematology Journal. 2000 ; Vol. 1, No. 1. pp. 37-41.
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AU - Nemes, L.

AU - Rintelen, C.

AU - Koder, S.

AU - Lechler, E.

AU - Loreth, R. M.

AU - Kyrle, P. A.

AU - Scharrer, I.

AU - Sas, G.

AU - Lechner, K.

AU - Mannhalter, C.

AU - Ehrenforth, S.

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N2 - Introduction: To evaluate the pregnancy-associated risk of venous thromboembolism and the risk of stillbirth and miscarriage a multicenter, retrospective and controlled study was conducted in women carrying the homozygous factor V Leiden mutation and in an age-matched control group of women from the normal population. Patients and methods: In 64 homozygous (median age 44 years, range 21-75 years) and in 52 control women from five different centers data on venous thromboembolism and pregnancy outcome were obtained. Results: The 64 homozygous women had in total 212 pregnancies, the 52 control women had 118 pregnancies. In homozygous women 65% of pregnancies ended with delivery of a viable infant, 15% with fetal loss (3.3% stillbirth, 12% miscarriage) and 20% by pregnancy termination. In the control women 75% of pregnancies ended with delivery of a viable infant, 12% with fetal loss (1.7% stillbirth, 10% miscarriage) and 13% by pregnancy termination. The differences were statistically not significant. Venous thromboembolism occurred significantly more often in the homozygous women, in 4.2% (9/212) during pregnancy and in 4.7% (10/212) after delivery or pregnancy termination. None of the control women had a thromboembolic episode. Conclusion: Our data indicate that women with homozygous factor V Leiden have a high probability for a favorable pregnancy outcome. The increased risk for venous thromboembolism during pregnancy and after delivery would favor heparin prophylaxis during and after pregnancy in women homozygous for factor V Leiden.

AB - Introduction: To evaluate the pregnancy-associated risk of venous thromboembolism and the risk of stillbirth and miscarriage a multicenter, retrospective and controlled study was conducted in women carrying the homozygous factor V Leiden mutation and in an age-matched control group of women from the normal population. Patients and methods: In 64 homozygous (median age 44 years, range 21-75 years) and in 52 control women from five different centers data on venous thromboembolism and pregnancy outcome were obtained. Results: The 64 homozygous women had in total 212 pregnancies, the 52 control women had 118 pregnancies. In homozygous women 65% of pregnancies ended with delivery of a viable infant, 15% with fetal loss (3.3% stillbirth, 12% miscarriage) and 20% by pregnancy termination. In the control women 75% of pregnancies ended with delivery of a viable infant, 12% with fetal loss (1.7% stillbirth, 10% miscarriage) and 13% by pregnancy termination. The differences were statistically not significant. Venous thromboembolism occurred significantly more often in the homozygous women, in 4.2% (9/212) during pregnancy and in 4.7% (10/212) after delivery or pregnancy termination. None of the control women had a thromboembolic episode. Conclusion: Our data indicate that women with homozygous factor V Leiden have a high probability for a favorable pregnancy outcome. The increased risk for venous thromboembolism during pregnancy and after delivery would favor heparin prophylaxis during and after pregnancy in women homozygous for factor V Leiden.

KW - APC resistance

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