Pregnancy associated glycoproteins in ruminants: Inactive members of the aspartic proteinase family

J. F. Beckers, P. V. Drion, J. M. Garbayo, Zs Perényi, A. Zarrouk, J. Sulon, B. Remy, O. Szenci

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase family. Pepsinogen, renin, cathepsin E & D and chymosine are typical members of this family, characterised by the presence of aspartic acids boarding the recognition sites. Secreted in the peripheral blood of the pregnant female from early pregnancy, these proteins can be used in serological tests for establishing different diagnoses. In the veterinary practice, these diagnoses are useful for both pregnancy confirmation and follow-up of trophoblastic function. The first aspect can help breeders in the management of reproduction, while the second one more specifically concerns clinicians and researchers wishing to establish a differential diagnosis of pathologic conditions affecting pregnancy.

Original languageEnglish
Pages (from-to)461-469
Number of pages9
JournalActa veterinaria Hungarica
Volume47
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Cow
  • Goat
  • Pregnancy associated glycoproteins
  • Sheep

ASJC Scopus subject areas

  • veterinary(all)

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    Beckers, J. F., Drion, P. V., Garbayo, J. M., Perényi, Z., Zarrouk, A., Sulon, J., Remy, B., & Szenci, O. (1999). Pregnancy associated glycoproteins in ruminants: Inactive members of the aspartic proteinase family. Acta veterinaria Hungarica, 47(4), 461-469. https://doi.org/10.1556/avet.47.1999.4.6