Atenolol tartalmú oldat preformulálási vizsgálatai I. A hostabilitás pH-függése

Translated title of the contribution: Preformulation study of atenolol containing solutions. I. The ph dependence of thermostability

S. Marton, A. Hatem, G. Csóka, I. Rácz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 °C. A specific and sensitive HPLC method was adapted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4 with a k value of 1.1-10-3 h-1. The degradation of atenolol followed first-order kinetics at above mentioned conditions.

Original languageHungarian
Pages (from-to)192-195
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume71
Issue number2
Publication statusPublished - 2001

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Atenolol
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Atenolol tartalmú oldat preformulálási vizsgálatai I. A hostabilitás pH-függése. / Marton, S.; Hatem, A.; Csóka, G.; Rácz, I.

In: Acta Pharmaceutica Hungarica, Vol. 71, No. 2, 2001, p. 192-195.

Research output: Contribution to journalArticle

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