Preformulation studies of atenolol in oral liquid dosage form. I. Effect of pH and temperature

Adel Hatem, Sylvia Marton, Gabriella Csóka, István Rácz

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Abstract

The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 °C. A specific and sensitive HPLC method was adopted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4. The degradation of atenolol followed first-order kinetics at 90 °C, pH 4 with k value of 1.1·10 -3 hour -1.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalActa pharmaceutica Hungarica
Volume66
Issue number4
Publication statusPublished - Jul 1 1996

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ASJC Scopus subject areas

  • Pharmaceutical Science

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