Preformulation studies of atenolol in oral liquid dosage form. I. Effect of pH and temperature

Adel Hatem, Sylvia Marton, Gabriella Csóka, I. Rácz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 °C. A specific and sensitive HPLC method was adopted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4. The degradation of atenolol followed first-order kinetics at 90 °C, pH 4 with k value of 1.1·10 -3 hour -1.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume66
Issue number4
Publication statusPublished - Jul 1996

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Atenolol
Dosage Forms
Temperature
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Preformulation studies of atenolol in oral liquid dosage form. I. Effect of pH and temperature. / Hatem, Adel; Marton, Sylvia; Csóka, Gabriella; Rácz, I.

In: Acta Pharmaceutica Hungarica, Vol. 66, No. 4, 07.1996, p. 177-180.

Research output: Contribution to journalArticle

Hatem, Adel ; Marton, Sylvia ; Csóka, Gabriella ; Rácz, I. / Preformulation studies of atenolol in oral liquid dosage form. I. Effect of pH and temperature. In: Acta Pharmaceutica Hungarica. 1996 ; Vol. 66, No. 4. pp. 177-180.
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