The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 °C. A specific and sensitive HPLC method was adopted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4. The degradation of atenolol followed first-order kinetics at 90 °C, pH 4 with k value of 1.1·10 -3 hour -1.
|Number of pages||4|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Jul 1 1996|
ASJC Scopus subject areas
- Pharmaceutical Science