Preferential vulnerability of dendrites to lithium ion in rat brain and in nerve cell culture.

Z. Janka, I. Szentistvanyi, E. Kiraly, A. Párducz, A. Juhász, F. Joo

Research output: Contribution to journalArticle

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Abstract

Preferential swelling and vacuolation of dendrites were observed electron microscopically in different brain regions of rats treated with LiCl in a dose of 6-18 mmol/kg for 1-6 days. The most severe fine structural changes were revealed in the hippocampus. Low-dose (0.33 mmol/kg) lithium treatment lasting for a year did not cause any morphologically detectable alterations in the rat brain. In vitro studies showed a reduction of dendro-axonal process network of neurons measured by morphometric means after lithium exposure. Using different cultures of neuronal and glial cell populations, higher lithium uptake was observed for neuron-enriched cultures.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalActa neuropathologica. Supplementum
Volume7
Publication statusPublished - 1981

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Dendrites
Lithium
Cell Culture Techniques
Ions
Neurons
Brain
Neuroglia
Hippocampus
Electrons
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Preferential vulnerability of dendrites to lithium ion in rat brain and in nerve cell culture. / Janka, Z.; Szentistvanyi, I.; Kiraly, E.; Párducz, A.; Juhász, A.; Joo, F.

In: Acta neuropathologica. Supplementum, Vol. 7, 1981, p. 44-47.

Research output: Contribution to journalArticle

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AU - Juhász, A.

AU - Joo, F.

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