Predictors of survival in 171 patients with systemic sclerosis (Scleroderma)

Z. Nagy, L. Czirják

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Predictors of survival were determined in 171 patients with systemic sclerosis by univariate analysis, and the Cox proportional hazards model using both cross sectional data at entry into the follow-up and time- dependent follow-up data. Clinical and laboratory data were evaluated from 1982 to the end of 1993. The presence of diffuse scleroderma, kidney and cardiac involvements were unfavourable prognostic signs in both the univariate analysis, and the Cox proportional hazards models. The Cox model, using the variables detected at study entry, indicated that pericarditis, and anaemia were bad prognostic signs. Analysis with time dependent data has not been reported in systemic sclerosis. The appearance of pigmentation disturbances, anaemia, and respiratory failure during the follow-up also caused a poor prognosis of the disease by the Cox model. In the stepwise selection models, diffuse scleroderma, internal organ manifestations including renal, and cardiac involvements were predominantly selected as the most unfavourable factors for survival. As to the extent of skin involvement and internal organ manifestations, the general behaviour of the disease seems to be similar throughout the world. The early appearance of pericarditis and pigmentation disturbances at study entry are bad prognostic signs.

Original languageEnglish
Pages (from-to)454-460
Number of pages7
JournalClinical Rheumatology
Volume16
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Systemic Scleroderma
Proportional Hazards Models
Diffuse Scleroderma
Pericarditis
Survival
Pigmentation
Anemia
Kidney
Respiratory Insufficiency
Skin

Keywords

  • Prognosis
  • Scleroderma
  • Survival
  • Systemic Sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Predictors of survival in 171 patients with systemic sclerosis (Scleroderma). / Nagy, Z.; Czirják, L.

In: Clinical Rheumatology, Vol. 16, No. 5, 1997, p. 454-460.

Research output: Contribution to journalArticle

@article{d09dfc1834fc40d9879cf2229a439644,
title = "Predictors of survival in 171 patients with systemic sclerosis (Scleroderma)",
abstract = "Predictors of survival were determined in 171 patients with systemic sclerosis by univariate analysis, and the Cox proportional hazards model using both cross sectional data at entry into the follow-up and time- dependent follow-up data. Clinical and laboratory data were evaluated from 1982 to the end of 1993. The presence of diffuse scleroderma, kidney and cardiac involvements were unfavourable prognostic signs in both the univariate analysis, and the Cox proportional hazards models. The Cox model, using the variables detected at study entry, indicated that pericarditis, and anaemia were bad prognostic signs. Analysis with time dependent data has not been reported in systemic sclerosis. The appearance of pigmentation disturbances, anaemia, and respiratory failure during the follow-up also caused a poor prognosis of the disease by the Cox model. In the stepwise selection models, diffuse scleroderma, internal organ manifestations including renal, and cardiac involvements were predominantly selected as the most unfavourable factors for survival. As to the extent of skin involvement and internal organ manifestations, the general behaviour of the disease seems to be similar throughout the world. The early appearance of pericarditis and pigmentation disturbances at study entry are bad prognostic signs.",
keywords = "Prognosis, Scleroderma, Survival, Systemic Sclerosis",
author = "Z. Nagy and L. Czirj{\'a}k",
year = "1997",
doi = "10.1007/BF02238937",
language = "English",
volume = "16",
pages = "454--460",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer London",
number = "5",

}

TY - JOUR

T1 - Predictors of survival in 171 patients with systemic sclerosis (Scleroderma)

AU - Nagy, Z.

AU - Czirják, L.

PY - 1997

Y1 - 1997

N2 - Predictors of survival were determined in 171 patients with systemic sclerosis by univariate analysis, and the Cox proportional hazards model using both cross sectional data at entry into the follow-up and time- dependent follow-up data. Clinical and laboratory data were evaluated from 1982 to the end of 1993. The presence of diffuse scleroderma, kidney and cardiac involvements were unfavourable prognostic signs in both the univariate analysis, and the Cox proportional hazards models. The Cox model, using the variables detected at study entry, indicated that pericarditis, and anaemia were bad prognostic signs. Analysis with time dependent data has not been reported in systemic sclerosis. The appearance of pigmentation disturbances, anaemia, and respiratory failure during the follow-up also caused a poor prognosis of the disease by the Cox model. In the stepwise selection models, diffuse scleroderma, internal organ manifestations including renal, and cardiac involvements were predominantly selected as the most unfavourable factors for survival. As to the extent of skin involvement and internal organ manifestations, the general behaviour of the disease seems to be similar throughout the world. The early appearance of pericarditis and pigmentation disturbances at study entry are bad prognostic signs.

AB - Predictors of survival were determined in 171 patients with systemic sclerosis by univariate analysis, and the Cox proportional hazards model using both cross sectional data at entry into the follow-up and time- dependent follow-up data. Clinical and laboratory data were evaluated from 1982 to the end of 1993. The presence of diffuse scleroderma, kidney and cardiac involvements were unfavourable prognostic signs in both the univariate analysis, and the Cox proportional hazards models. The Cox model, using the variables detected at study entry, indicated that pericarditis, and anaemia were bad prognostic signs. Analysis with time dependent data has not been reported in systemic sclerosis. The appearance of pigmentation disturbances, anaemia, and respiratory failure during the follow-up also caused a poor prognosis of the disease by the Cox model. In the stepwise selection models, diffuse scleroderma, internal organ manifestations including renal, and cardiac involvements were predominantly selected as the most unfavourable factors for survival. As to the extent of skin involvement and internal organ manifestations, the general behaviour of the disease seems to be similar throughout the world. The early appearance of pericarditis and pigmentation disturbances at study entry are bad prognostic signs.

KW - Prognosis

KW - Scleroderma

KW - Survival

KW - Systemic Sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0030866707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030866707&partnerID=8YFLogxK

U2 - 10.1007/BF02238937

DO - 10.1007/BF02238937

M3 - Article

C2 - 9348139

AN - SCOPUS:0030866707

VL - 16

SP - 454

EP - 460

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 5

ER -