Predictive morphological findings in "zero-hour" biopsies of renal allografts.

J. Szánya, P. Szakály, T. Magyarlaki, Z. Balogh, J. Nagy, K. K. Nagy

Research output: Contribution to journalArticle

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Abstract

"Zero-hour" biopsies of 65 donors have been performed since 1994. Donor kidneys were categorized into five groups based on the morphological findings in "zero-hour" biopsies. No morphological abnormalities were found in 38% of the cases (group 1). Arteriosclerosis was present in 31% of donor kidneys (group 2). Specific morphological alterations, i.e. acute tubular necrosis [21.5%], tubulointerstitial nephritis [6.2%] or glomerulonephritis [3.1%] were detectable in the cases remained (group 3-5). During an average of 336 posttransplant days clinical and histological follow up was performed (50 rebiopsies). Statistical data of mismatch (1.4-2.0), average of donor/recipient age (35-42 years), cold and warm ischaemic time (1290 and 66 min) were comparable in all groups. According to our observations: 1. higher creatinin was found in grafts with arteriosclerosis (group 2) (p <0.05), 2. there were more non-viable grafts and longer period of delayed graft function in acute tubular necrosis (group 3), 3 higher creatinin, rejections with the need of rehemodialysis were observed in four cases of tubulointerstitial nephritis (TIN-group 4). Glomerulonephritis (GN-group 5) grafts had only delayed graft function, however these groups were few for statistical evaluation. Biopsy complication in 1/115 cases was found (rebiopsy induced kidney haemorrhage). In conclusion, "zero-hour" biopsies can be useful and safe tools to predict early graft function. Besides "zero-hour" biopsies help the histological interpretation of consecutive graft rebiopsies.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

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Allografts
Transplants
Kidney
Biopsy
Delayed Graft Function
Interstitial Nephritis
Arteriosclerosis
Glomerulonephritis
Necrosis
Cold Ischemia
Warm Ischemia
Hemorrhage

ASJC Scopus subject areas

  • Surgery

Cite this

Predictive morphological findings in "zero-hour" biopsies of renal allografts. / Szánya, J.; Szakály, P.; Magyarlaki, T.; Balogh, Z.; Nagy, J.; Nagy, K. K.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 346-348.

Research output: Contribution to journalArticle

Szánya, J, Szakály, P, Magyarlaki, T, Balogh, Z, Nagy, J & Nagy, KK 1997, 'Predictive morphological findings in "zero-hour" biopsies of renal allografts.', Acta Chirurgica Hungarica, vol. 36, no. 1-4, pp. 346-348.
Szánya, J. ; Szakály, P. ; Magyarlaki, T. ; Balogh, Z. ; Nagy, J. ; Nagy, K. K. / Predictive morphological findings in "zero-hour" biopsies of renal allografts. In: Acta Chirurgica Hungarica. 1997 ; Vol. 36, No. 1-4. pp. 346-348.
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