Predictive factors of sustained virological response for recurrent hepatitis C virus after liver transplantation: The Hungarian experience

B. Nemes, F. Gelley, G. Zádori, A. Kiss, P. Nagy, Z. Gerlei, G. Lengyel, E. Sárváry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recurrence of hepatitis C virus (HCV) after liver transplantation (OLT) occurs consistently. Early initiation of combined antiviral treatment (AVT) has become a standard treatment seeking to achieve sustained virological response (SVR). We evaluated the files of 108 HCV-positive patients between 2003 and 2010. Seventy-two (72) experienced recurrent HCV within 12 months, 31 of whom completed the AVT (43%) but 9 (29%) exhibited SVR. Factors with impacting SVR were male recipient, no fatty changes in the donor liver, short warm ischemia time, cyclosporine-based immunosuppression, neither infective, septic or bleeding complication nor acute rejection episode and a rapid viral response to AVT. De novo diabetes, and unsuccessful AVT prior to OLT were strongly associated with a a failed SVR. The 1- and 3-year cumulative patient survival rates trended to be better in cases of SVR compared with nonresponders (100% and 100% versus 94% and 89%; P =.07).

Original languageEnglish
Pages (from-to)2162-2163
Number of pages2
JournalTransplantation proceedings
Volume44
Issue number7
DOIs
Publication statusPublished - Sep 1 2012

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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