Predictions of which diastereoisomeric salt precipitates during an optical resolution via diastereoisomeric salt formation

David Kozma, Mária Ács, E. Fogassy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The DSC data of sixteen conglomerate forming diastereoisomeric salt pairs were analysed. It was demonstrated that during optical resolution via fractional crystallization of diastereoisomeric salt pairs always that diastereoisomeric salt precipitates which has the higher melting point. When one of the salts is amorphous that remains in the mother liquor. If one of the diastereoisomeric salt crystallizes with solvate that will precipitate during optical resolutions.

Original languageEnglish
Pages (from-to)6907-6912
Number of pages6
JournalTetrahedron
Volume50
Issue number23
DOIs
Publication statusPublished - 1994

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Precipitates
Salts
Crystallization
Freezing
Melting point

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Predictions of which diastereoisomeric salt precipitates during an optical resolution via diastereoisomeric salt formation. / Kozma, David; Ács, Mária; Fogassy, E.

In: Tetrahedron, Vol. 50, No. 23, 1994, p. 6907-6912.

Research output: Contribution to journalArticle

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