Predicting effective drug combinations via network propagation

Balázs Ligeti, Roberto Vera, Gergely Lukács, B. Györffy, Sándor Pongor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Drug combinations are frequently used in treating complex diseases including cancer, diabetes, arthritis and hypertension. Most drug combinations were found in empirical ways so there is a need of efficient computational methods. Here we present a novel method based on network analysis which estimates the efficacy of drug combinations from a perturbation analysis performed on a protein-protein association network. The results suggest that those drugs are likely to form effective combinations that perturb a large number of proteins in common, even if the original targets are found in seemingly unrelated pathways.

Original languageEnglish
Title of host publication2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
Pages378-381
Number of pages4
DOIs
Publication statusPublished - 2013
Event2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 - Rotterdam, Netherlands
Duration: Oct 31 2013Nov 2 2013

Other

Other2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
CountryNetherlands
CityRotterdam
Period10/31/1311/2/13

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Proteins
Medical problems
Electric network analysis
Computational methods

ASJC Scopus subject areas

  • Hardware and Architecture
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Ligeti, B., Vera, R., Lukács, G., Györffy, B., & Pongor, S. (2013). Predicting effective drug combinations via network propagation. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 (pp. 378-381). [6679718] https://doi.org/10.1109/BioCAS.2013.6679718

Predicting effective drug combinations via network propagation. / Ligeti, Balázs; Vera, Roberto; Lukács, Gergely; Györffy, B.; Pongor, Sándor.

2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 378-381 6679718.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ligeti, B, Vera, R, Lukács, G, Györffy, B & Pongor, S 2013, Predicting effective drug combinations via network propagation. in 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013., 6679718, pp. 378-381, 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013, Rotterdam, Netherlands, 10/31/13. https://doi.org/10.1109/BioCAS.2013.6679718
Ligeti B, Vera R, Lukács G, Györffy B, Pongor S. Predicting effective drug combinations via network propagation. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 378-381. 6679718 https://doi.org/10.1109/BioCAS.2013.6679718
Ligeti, Balázs ; Vera, Roberto ; Lukács, Gergely ; Györffy, B. ; Pongor, Sándor. / Predicting effective drug combinations via network propagation. 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. pp. 378-381
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