Prediabetes: A high-risk state for diabetes development

Adam G. Tabák, Christian Herder, Wolfgang Rathmann, Eric J. Brunner, Mika Kivimäki

Research output: Contribution to journalReview article

878 Citations (Scopus)

Abstract

Prediabetes (intermediate hyperglycaemia) is a high-risk state for diabetes that is defined by glycaemic variables that are higher than normal, but lower than diabetes thresholds. 5-10% of people per year with prediabetes will progress to diabetes, with the same proportion converting back to normoglycaemia. Prevalence of prediabetes is increasing worldwide and experts have projected that more than 470 million people will have prediabetes by 2030. Prediabetes is associated with the simultaneous presence of insulin resistance and β-cell dysfunction-abnormalities that start before glucose changes are detectable. Observational evidence shows associations between prediabetes and early forms of nephropathy, chronic kidney disease, small fibre neuropathy, diabetic retinopathy, and increased risk of macrovascular disease. Multifactorial risk scores using non-invasive measures and blood-based metabolic traits, in addition to glycaemic values, could optimise estimation of diabetes risk. For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention, with evidence of a 40-70% relative-risk reduction. Accumulating data also show potential benefits from pharmacotherapy.

Original languageEnglish
Pages (from-to)2279-2290
Number of pages12
JournalThe Lancet
Volume379
Issue number9833
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Medicine(all)

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    Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012). Prediabetes: A high-risk state for diabetes development. The Lancet, 379(9833), 2279-2290. https://doi.org/10.1016/S0140-6736(12)60283-9