Precuneus-dominant degeneration of parietal lobe is at risk of epilepsy in mild alzheimer’s disease

Andras Horvath, Mate Kiss, A. Szűcs, A. Kamondi

Research output: Contribution to journalArticle

Abstract

Introduction: Alzheimer’s disease (AD) is the leading cause of cognitive decline. Epilepsy is a frequent comorbid condition of AD. While previous studies analyzed the risk factors of AD-related epileptic seizures, we still lack biomarkers of epilepsy in mild AD cases. Purpose: The aim of our study was to analyze the correlations between neuropsychology, cortical thickness, and brain volumetric measurements in mild Alzheimer patients with concomitant epileptic seizures. Materials and methods: We selected mild AD patients from our database to examine them with structural magnetic resonance imaging, 24 h electroencephalography, and detailed neuropsychology. We made the diagnosis of epilepsy based on epileptology data including neurophysiology. We retrospectively analyzed the neuropsychology pattern, clinical and epidemiologic features, cortical thickness, and volumetric values of mild AD patients with and without overt clinical seizures using covariance weighted general linear model. Results: We found epileptic seizures in 26% of mild AD patients. Patients with seizures performed worse in visuo-spatial scores than patients without (p = 0.003). Patients with seizures had smaller parietal thickness (p = 0.018), being associated to reduced thickness of left (p = 0.007), and right precunei (p = 0.005). The visuo-spatial performance positively and strongly correlated with the thickness of the parietal lobe (r = 0.67; p = 0.002) and with the volume of the precuneus (r = 0.612; p = 0.005). Conclusion: Epileptic seizures are common even in mild AD. We found that a prominent deficit in visuo-spatial skills is a red flag for epileptic seizures in the initial phase of AD, indicating the early involvement of parietal lobe in the neurodegenerative process. Because our findings suggest that the degeneration of precuneus is a sensitive marker of seizures associated to mild AD, clinicians need to pay special attention to the pattern of atrophy shown by structural MRI. Our results confirm previous data suggesting that epileptic seizures might be associated to a faster progressing type of AD with the early degeneration of posterior cortical areas.

Original languageEnglish
Article number878
JournalFrontiers in Neurology
Volume10
Issue numberAUG
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Parietal Lobe
Neuroimaging
Epilepsy
Alzheimer Disease
Seizures
Neuropsychology
Neurophysiology
Atrophy
Electroencephalography
Linear Models
Biomarkers
Magnetic Resonance Imaging
Databases

Keywords

  • Alzheimer’s disease
  • Epilepsy
  • Neuroimaging
  • Parietal lobe
  • Precuneus
  • Seizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Precuneus-dominant degeneration of parietal lobe is at risk of epilepsy in mild alzheimer’s disease. / Horvath, Andras; Kiss, Mate; Szűcs, A.; Kamondi, A.

In: Frontiers in Neurology, Vol. 10, No. AUG, 878, 01.01.2019.

Research output: Contribution to journalArticle

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