Preconception venous thromboembolism and placenta-mediated pregnancy complications

A. T. Hansen, M. Schmidt, E. Puhó, L. Pedersen, K. J. Rothman, A. M. Hvas, H. T. Sørensen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Placenta-mediated complications are leading causes of maternal and fetal morbidity and mortality. We hypothesized that a preconception history of venous thromboembolism (VTE) is associated with increased risk of placenta-mediated pregnancy complications. Methods: A nationwide population-based cohort study of all singleton pregnancies leading to delivery from 1997 to 2012 (n = 964 967). We obtained data on placenta-mediated pregnancy complications from the Danish Medical Birth Registry and data on VTE before pregnancy from the Danish National Patient Registry. We computed absolute risks, crude and adjusted risk differences (RDs) using a binomial regression model, and crude and adjusted risk ratios (RRs) from a modified Poisson regression model. Results: Overall, 1419 women had a preconception history of VTE, while 578 112 did not. Preeclampsia occurred in 4.2% of pregnancies in the VTE group and in 2.7% of pregnancies in a comparison cohort (adjusted RD = 1.3%, 95% confidence interval (CI) 0.6-2.0%; adjusted RR = 1.5, 95% CI 1.3-1.8). Stillbirth occurred in 0.7% of pregnancies in the VTE group and in 0.4% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI 0.02-0.6%; adjusted RR = 1.8, 95% CI 1.1-3.0). Placental abruption occurred in 0.8% of pregnancies in the VTE group and in 0.5% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI - 0.05-0.6%; adjusted RR = 1.6, 95% CI 1.1-2.4). Small-for-gestational-age infants accounted for 10.9% of live births in the VTE group and 9.8% of live births in the comparison cohort (adjusted RD = 0.6%, 95% CI - 0.5-1.7%; adjusted RR = 1.1, 95% CI 0.9-1.3). Conclusion: Women with a history of VTE were at increased risk of placenta-mediated complications.

Original languageEnglish
Pages (from-to)1635-1641
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume13
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Pregnancy Complications
Venous Thromboembolism
Placenta
Confidence Intervals
Pregnancy
Odds Ratio
Live Birth
Registries
Small for Gestational Age Infant
Abruptio Placentae
Fetal Mortality
Stillbirth
Statistical Models
Pre-Eclampsia
Cohort Studies
Mothers
Parturition
Morbidity

Keywords

  • Abruptio placentae
  • Cohort study
  • Infant, small-for-gestational age
  • Preeclampsia
  • Stillbirth
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Cite this

Hansen, A. T., Schmidt, M., Puhó, E., Pedersen, L., Rothman, K. J., Hvas, A. M., & Sørensen, H. T. (2015). Preconception venous thromboembolism and placenta-mediated pregnancy complications. Journal of Thrombosis and Haemostasis, 13(9), 1635-1641. https://doi.org/10.1111/jth.13046

Preconception venous thromboembolism and placenta-mediated pregnancy complications. / Hansen, A. T.; Schmidt, M.; Puhó, E.; Pedersen, L.; Rothman, K. J.; Hvas, A. M.; Sørensen, H. T.

In: Journal of Thrombosis and Haemostasis, Vol. 13, No. 9, 01.09.2015, p. 1635-1641.

Research output: Contribution to journalArticle

Hansen, AT, Schmidt, M, Puhó, E, Pedersen, L, Rothman, KJ, Hvas, AM & Sørensen, HT 2015, 'Preconception venous thromboembolism and placenta-mediated pregnancy complications', Journal of Thrombosis and Haemostasis, vol. 13, no. 9, pp. 1635-1641. https://doi.org/10.1111/jth.13046
Hansen, A. T. ; Schmidt, M. ; Puhó, E. ; Pedersen, L. ; Rothman, K. J. ; Hvas, A. M. ; Sørensen, H. T. / Preconception venous thromboembolism and placenta-mediated pregnancy complications. In: Journal of Thrombosis and Haemostasis. 2015 ; Vol. 13, No. 9. pp. 1635-1641.
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AU - Schmidt, M.

AU - Puhó, E.

AU - Pedersen, L.

AU - Rothman, K. J.

AU - Hvas, A. M.

AU - Sørensen, H. T.

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N2 - Background: Placenta-mediated complications are leading causes of maternal and fetal morbidity and mortality. We hypothesized that a preconception history of venous thromboembolism (VTE) is associated with increased risk of placenta-mediated pregnancy complications. Methods: A nationwide population-based cohort study of all singleton pregnancies leading to delivery from 1997 to 2012 (n = 964 967). We obtained data on placenta-mediated pregnancy complications from the Danish Medical Birth Registry and data on VTE before pregnancy from the Danish National Patient Registry. We computed absolute risks, crude and adjusted risk differences (RDs) using a binomial regression model, and crude and adjusted risk ratios (RRs) from a modified Poisson regression model. Results: Overall, 1419 women had a preconception history of VTE, while 578 112 did not. Preeclampsia occurred in 4.2% of pregnancies in the VTE group and in 2.7% of pregnancies in a comparison cohort (adjusted RD = 1.3%, 95% confidence interval (CI) 0.6-2.0%; adjusted RR = 1.5, 95% CI 1.3-1.8). Stillbirth occurred in 0.7% of pregnancies in the VTE group and in 0.4% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI 0.02-0.6%; adjusted RR = 1.8, 95% CI 1.1-3.0). Placental abruption occurred in 0.8% of pregnancies in the VTE group and in 0.5% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI - 0.05-0.6%; adjusted RR = 1.6, 95% CI 1.1-2.4). Small-for-gestational-age infants accounted for 10.9% of live births in the VTE group and 9.8% of live births in the comparison cohort (adjusted RD = 0.6%, 95% CI - 0.5-1.7%; adjusted RR = 1.1, 95% CI 0.9-1.3). Conclusion: Women with a history of VTE were at increased risk of placenta-mediated complications.

AB - Background: Placenta-mediated complications are leading causes of maternal and fetal morbidity and mortality. We hypothesized that a preconception history of venous thromboembolism (VTE) is associated with increased risk of placenta-mediated pregnancy complications. Methods: A nationwide population-based cohort study of all singleton pregnancies leading to delivery from 1997 to 2012 (n = 964 967). We obtained data on placenta-mediated pregnancy complications from the Danish Medical Birth Registry and data on VTE before pregnancy from the Danish National Patient Registry. We computed absolute risks, crude and adjusted risk differences (RDs) using a binomial regression model, and crude and adjusted risk ratios (RRs) from a modified Poisson regression model. Results: Overall, 1419 women had a preconception history of VTE, while 578 112 did not. Preeclampsia occurred in 4.2% of pregnancies in the VTE group and in 2.7% of pregnancies in a comparison cohort (adjusted RD = 1.3%, 95% confidence interval (CI) 0.6-2.0%; adjusted RR = 1.5, 95% CI 1.3-1.8). Stillbirth occurred in 0.7% of pregnancies in the VTE group and in 0.4% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI 0.02-0.6%; adjusted RR = 1.8, 95% CI 1.1-3.0). Placental abruption occurred in 0.8% of pregnancies in the VTE group and in 0.5% of pregnancies in the comparison cohort (adjusted RD = 0.3%, 95% CI - 0.05-0.6%; adjusted RR = 1.6, 95% CI 1.1-2.4). Small-for-gestational-age infants accounted for 10.9% of live births in the VTE group and 9.8% of live births in the comparison cohort (adjusted RD = 0.6%, 95% CI - 0.5-1.7%; adjusted RR = 1.1, 95% CI 0.9-1.3). Conclusion: Women with a history of VTE were at increased risk of placenta-mediated complications.

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