Preclinical and clinical studies with somatostatin related to the central nervous system

Lászlo Vécsei, Erik Widerlöv

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

1. The tetradecapeptide somatostatin (SS) has a widespread, uneven distribution within several organs including the central nervous system (CNS), with particularly high concentration in the hypothalamus. 2. The SS-related peptides (SS28, SS28(1-12), SS28(15-28)) are originated from the precursor pre-prosomatostatin. 3. SS is suggested to be involved in a large number of CNS functions, locomotion, sedation, excitation, catatonia, body temperature, feeding, nociception, paradoxical sleep, self-stimulation, seizure, learning and memory. 4. SS influences central neurochemical processes. 5. It is possible that SS is related to various neurological and psychiatric illnesses, like Huntington's disease, multiple sclerosis, Parkinson's disease, epilepsy, eating disorders, Alzheimer's disease, schizophrenia and major depressive illness.

Original languageEnglish
Pages (from-to)473-502
Number of pages30
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume14
Issue number4
DOIs
Publication statusPublished - 1990

Keywords

  • animal behavior
  • neurochemistry
  • neurologic disorders
  • psychiatric disorders
  • somatostatin

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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