Preclinical abnormality of left ventricular performance in patients with insulin-dependent diabetes mellitus

György Jermendy, László Kammerer, Szófia M. Koltai, Livia Cserhalmi, Judit Szelényi, Maria Tichy, Gábor Pogátsa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The left ventricular systolic function of 32 patients with insulin-dependent diabetes mellitus was investigated by measurement of systolic time intervals. Patients with clinical signs of sclerosis in the coronary arteries were excluded. Twenty-nine sex- and age-matched healthy people served as controls. Resting values of PEP/LVET ratio and of the corrected pre-ejection period were significantly higher in diabetics than in controls. The alterations of systolic time intervals during volume-loading induced by passive leg-raising as well as by isometric handgrip test indicated an increase in left ventricular performance in healthy people. The unchanged systolic time intervals observed in diabetics during the same loadings indicated a decrease in the functional reserve of the diabetic left ventricle. The systolic time intervals observed in patients with type-1 diabetes could be evaluated as a preclinical abnormality of left ventricular performance and as early signs of diabetic cardiomyopathy.

Original languageEnglish
Pages (from-to)311-320
Number of pages10
JournalActa Diabetologica Latina
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 1 1983

Keywords

  • Diabetic cardiomyopathy
  • Handgrip test
  • Insulin-dependent diabetes mellitus
  • Systolic time intervals
  • Volume-loading

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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