Prealbumin as a hapten carrier protein in certain varieties of dermatitis

Sándor Husz, János Hunyadi, Attila Dobozy, Anna Sz Kenderessy, Éva Szabó, Nikolaus Simon

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Abstract

A significant decrease of serum prealbumin levels and an increased proportion of prealbumin bearing lymphocytes in peripheral blood have been found in patients of hapten-induced diseases. Prealbumin deposition in the vessel walls, and/or prealbumin positive cells (granulocytes, lymphocytes, macrophages) in the dermis have been observed in patients with proved drug allergy as well as allergic contact dermatitis using immunofluorescence technique. The eluates from membrane of lymphocytes of patients with drug allergy contained a mitogenic substance, probably antigen and sometimes prealbumin as well. These results also support the earlier suggested hypothesis that the prealbumin may act as a hapten carrier protein.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalArchives of Dermatological Research
Volume264
Issue number3
DOIs
Publication statusPublished - Jan 1 1979

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Keywords

  • Elution from membrane of lymphocytes
  • Hapten carrier protein
  • Prealbumin

ASJC Scopus subject areas

  • Dermatology

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