Pre-transplant history of mental health concerns, non-adherence, and post-transplant outcomes in kidney transplant recipients

Franz Marie Gumabay, Marta Novak, Aarushi Bansal, Margot Mitchell, Olusegun Famure, S. Joseph Kim, Istvan Mucsi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective The association between pre-transplant mental health concerns and non-adherence and post-transplant outcomes after kidney transplantation is not fully established. We examined the relationship between a pre-transplant history of mental health concerns and non-adherence and post-transplant outcomes among kidney transplant recipients. Methods In this retrospective single center cohort study of adult kidney transplant recipients (n = 955) the associations between the history of mental health concerns or non-adherence and the time from kidney transplant to biopsy proven acute rejection; death-censored graft failure and total graft failure were examined using Cox proportional hazards models. Results Mean (SD) age was 51 (13) years, 61% were male and 27% had a history of diabetes. Twenty-two and 11% of patients had mental health concerns and non-adherence, respectively. Fifteen percent of the patients had acute rejection, 5.6% had death-censored graft failure and 13.0% had total graft failure. The history of mental health concerns was not associated with acute rejection, death-censored graft failure or total graft failure. Patients with versus without a history of non-adherence tended to have higher cumulative incidence of acute rejection (23.3% [95% CI: 16.1, 33.2] vs. 13.6% [95% CI: 11.4, 16.2]) and death-censored graft failure (15.0% [95% CI: 6.9, 30.8] vs. 6.4% [95% CI: 4.7, 8.7]) (log rank p = 0.052 and p = 0.086, respectively). These trends were not significant after multivariable adjustment. Conclusion In summary, a history of pre-transplant mental health concerns or non-adherence is not associated with adverse outcomes in patients who completed transplant workup and received a kidney transplant.

Original languageEnglish
Pages (from-to)115-124
Number of pages10
JournalJournal of Psychosomatic Research
Volume105
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Kidney transplantation
  • Mental health
  • Non-adherence
  • Outcomes

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Pre-transplant history of mental health concerns, non-adherence, and post-transplant outcomes in kidney transplant recipients'. Together they form a unique fingerprint.

  • Cite this