Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity

Simone Rampelli, Kathrin Guenther, Silvia Turroni, Maike Wolters, Toomas Veidebaum, Yiannis Kourides, D. Molnár, Lauren Lissner, Alfonso Benitez-Paez, Yolanda Sanz, Arno Fraterman, Nathalie Michels, Patrizia Brigidi, Marco Candela, Wolfgang Ahrens

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

It is widely accepted that the intestinal microbiome is connected to obesity, as key mediator of the diet impact on the host metabolic and immunological status. To investigate whether the individual gut microbiome has a potential in predicting the onset and progression of diseases, here we characterized the faecal microbiota of 70 children in a two-time point prospective study, within a four-year window. All children had normal weight at the beginning of this study, but 36 of them gained excessive weight at the subsequent check-up. Microbiome data were analysed together with the hosts’ diet information, physical activity, and inflammatory parameters. We find that the gut microbiota structures were stratified into a discrete number of groups, characterized by different biodiversity that correlates with inflammatory markers and dietary habits, regardless of age, gender, and body weight. Collectively, our data underscore the importance of the microbiome–host–diet configuration as a possible predictor of obesity.

Original languageEnglish
Article number222
JournalCommunications Biology
Volume1
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

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    Rampelli, S., Guenther, K., Turroni, S., Wolters, M., Veidebaum, T., Kourides, Y., Molnár, D., Lissner, L., Benitez-Paez, A., Sanz, Y., Fraterman, A., Michels, N., Brigidi, P., Candela, M., & Ahrens, W. (2018). Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity. Communications Biology, 1(1), [222]. https://doi.org/10.1038/s42003-018-0221-5