Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons

J. Szabadics, L. Erdelyi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that several authors described previously [3, 9]. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases the membrane potential of the neurons, increases the inward resistance and decreases the GABA, ACh and glutamate evoked excitatory responses in submillimolar concentration.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalActa biologica Hungarica
Volume51
Issue number2-4
Publication statusPublished - Sep 28 2000

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Keywords

  • Eugenol
  • Helix pomatia
  • Identified neurons
  • Membrane effects
  • Neurotransmitters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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