Practical experiences and in vitro and in vivo validation studies with a new gastric tonometric probe in human adult patients

Péter Palágyi, László Vimláti, K. Boda, Gyula Tálosi, Domokos Boda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: This study provides practical experiences with a new, simple, balloon-free gastric tonometric probe (probe) and reports the results of simultaneous in vitro and in vivo measurements with a conventional, ballooned gastric air tonometer (catheter) and the new device. Materials and Methods: Ten healthy volunteers and 50 anesthetized surgical patients with different American Society of Anesthesiologists (ASA) scores, scheduled for neurologic, orthopedic, trauma, and cardiac operations, were enrolled in the study. The values of 60 in vitro and, in 12 surgical patients, 101 in vivo paired Pco2 measurements-performed simultaneously with the new tonometric probe and the catheter that was connected to a Tonocap monitor-were compared. The tolerability of the measurement with the new probe was examined, and the results of gastric tonometry and, in surgical cases, the gastric tonometric, end-expiratory, and arterial Pco2 values were registered. The results were evaluated by analysis of variance test. The data of the in vivo paired measurements were evaluated by Bland-Altman analysis. Results: The use of the probe proved to be well tolerated and easily applicable in the studied cases. The results of 20 measurements obtained in healthy volunteers and those of 520 measurements in the surgical cases correspond to the data obtained with the classical methods published in the medical literature. During in vitro paired measurements, there was a good agreement between the data obtained with the 2 methods; however, in the in vivo studies, the results of measurements performed with the probe were mostly higher. Conclusions: The differences between the results obtained with the 2 methods might have been caused by the quicker equilibration property of the probe and by the fundamental differences between the 2 methods. The new probe seems to be applicable for routine human measurements.

Original languageEnglish
JournalJournal of Critical Care
Volume25
Issue number3
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Validation Studies
Stomach
Healthy Volunteers
Gastric Balloon
Catheters
Nervous System Trauma
Manometry
Orthopedics
Analysis of Variance
Air
In Vitro Techniques
Equipment and Supplies

Keywords

  • Carbon dioxide
  • Gastrointestinal tonometry
  • Measurement technique
  • Partial pressure
  • Validation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Practical experiences and in vitro and in vivo validation studies with a new gastric tonometric probe in human adult patients. / Palágyi, Péter; Vimláti, László; Boda, K.; Tálosi, Gyula; Boda, Domokos.

In: Journal of Critical Care, Vol. 25, No. 3, 09.2010.

Research output: Contribution to journalArticle

@article{635f6ec98ffc46c89b0cced0097cae44,
title = "Practical experiences and in vitro and in vivo validation studies with a new gastric tonometric probe in human adult patients",
abstract = "Purpose: This study provides practical experiences with a new, simple, balloon-free gastric tonometric probe (probe) and reports the results of simultaneous in vitro and in vivo measurements with a conventional, ballooned gastric air tonometer (catheter) and the new device. Materials and Methods: Ten healthy volunteers and 50 anesthetized surgical patients with different American Society of Anesthesiologists (ASA) scores, scheduled for neurologic, orthopedic, trauma, and cardiac operations, were enrolled in the study. The values of 60 in vitro and, in 12 surgical patients, 101 in vivo paired Pco2 measurements-performed simultaneously with the new tonometric probe and the catheter that was connected to a Tonocap monitor-were compared. The tolerability of the measurement with the new probe was examined, and the results of gastric tonometry and, in surgical cases, the gastric tonometric, end-expiratory, and arterial Pco2 values were registered. The results were evaluated by analysis of variance test. The data of the in vivo paired measurements were evaluated by Bland-Altman analysis. Results: The use of the probe proved to be well tolerated and easily applicable in the studied cases. The results of 20 measurements obtained in healthy volunteers and those of 520 measurements in the surgical cases correspond to the data obtained with the classical methods published in the medical literature. During in vitro paired measurements, there was a good agreement between the data obtained with the 2 methods; however, in the in vivo studies, the results of measurements performed with the probe were mostly higher. Conclusions: The differences between the results obtained with the 2 methods might have been caused by the quicker equilibration property of the probe and by the fundamental differences between the 2 methods. The new probe seems to be applicable for routine human measurements.",
keywords = "Carbon dioxide, Gastrointestinal tonometry, Measurement technique, Partial pressure, Validation",
author = "P{\'e}ter Pal{\'a}gyi and L{\'a}szl{\'o} Viml{\'a}ti and K. Boda and Gyula T{\'a}losi and Domokos Boda",
year = "2010",
month = "9",
doi = "10.1016/j.jcrc.2009.12.002",
language = "English",
volume = "25",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Practical experiences and in vitro and in vivo validation studies with a new gastric tonometric probe in human adult patients

AU - Palágyi, Péter

AU - Vimláti, László

AU - Boda, K.

AU - Tálosi, Gyula

AU - Boda, Domokos

PY - 2010/9

Y1 - 2010/9

N2 - Purpose: This study provides practical experiences with a new, simple, balloon-free gastric tonometric probe (probe) and reports the results of simultaneous in vitro and in vivo measurements with a conventional, ballooned gastric air tonometer (catheter) and the new device. Materials and Methods: Ten healthy volunteers and 50 anesthetized surgical patients with different American Society of Anesthesiologists (ASA) scores, scheduled for neurologic, orthopedic, trauma, and cardiac operations, were enrolled in the study. The values of 60 in vitro and, in 12 surgical patients, 101 in vivo paired Pco2 measurements-performed simultaneously with the new tonometric probe and the catheter that was connected to a Tonocap monitor-were compared. The tolerability of the measurement with the new probe was examined, and the results of gastric tonometry and, in surgical cases, the gastric tonometric, end-expiratory, and arterial Pco2 values were registered. The results were evaluated by analysis of variance test. The data of the in vivo paired measurements were evaluated by Bland-Altman analysis. Results: The use of the probe proved to be well tolerated and easily applicable in the studied cases. The results of 20 measurements obtained in healthy volunteers and those of 520 measurements in the surgical cases correspond to the data obtained with the classical methods published in the medical literature. During in vitro paired measurements, there was a good agreement between the data obtained with the 2 methods; however, in the in vivo studies, the results of measurements performed with the probe were mostly higher. Conclusions: The differences between the results obtained with the 2 methods might have been caused by the quicker equilibration property of the probe and by the fundamental differences between the 2 methods. The new probe seems to be applicable for routine human measurements.

AB - Purpose: This study provides practical experiences with a new, simple, balloon-free gastric tonometric probe (probe) and reports the results of simultaneous in vitro and in vivo measurements with a conventional, ballooned gastric air tonometer (catheter) and the new device. Materials and Methods: Ten healthy volunteers and 50 anesthetized surgical patients with different American Society of Anesthesiologists (ASA) scores, scheduled for neurologic, orthopedic, trauma, and cardiac operations, were enrolled in the study. The values of 60 in vitro and, in 12 surgical patients, 101 in vivo paired Pco2 measurements-performed simultaneously with the new tonometric probe and the catheter that was connected to a Tonocap monitor-were compared. The tolerability of the measurement with the new probe was examined, and the results of gastric tonometry and, in surgical cases, the gastric tonometric, end-expiratory, and arterial Pco2 values were registered. The results were evaluated by analysis of variance test. The data of the in vivo paired measurements were evaluated by Bland-Altman analysis. Results: The use of the probe proved to be well tolerated and easily applicable in the studied cases. The results of 20 measurements obtained in healthy volunteers and those of 520 measurements in the surgical cases correspond to the data obtained with the classical methods published in the medical literature. During in vitro paired measurements, there was a good agreement between the data obtained with the 2 methods; however, in the in vivo studies, the results of measurements performed with the probe were mostly higher. Conclusions: The differences between the results obtained with the 2 methods might have been caused by the quicker equilibration property of the probe and by the fundamental differences between the 2 methods. The new probe seems to be applicable for routine human measurements.

KW - Carbon dioxide

KW - Gastrointestinal tonometry

KW - Measurement technique

KW - Partial pressure

KW - Validation

UR - http://www.scopus.com/inward/record.url?scp=84755161835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84755161835&partnerID=8YFLogxK

U2 - 10.1016/j.jcrc.2009.12.002

DO - 10.1016/j.jcrc.2009.12.002

M3 - Article

VL - 25

JO - Journal of Critical Care

JF - Journal of Critical Care

SN - 0883-9441

IS - 3

ER -