INTRODUCTION - The importance of measuring microalbuminuria is well established, however, controversy still exists regarding the type of urine specimen to be used for detecting early renal impairment of diabetic patients. PATIENTS AND METHODS - To evaluate practical aspects, albumin concentration and albumin to creatinine ratio of first void urine samples as well as urinary albumin excretion in timed specimens were determined by immunoturbidimetric method 3 times within 3 weeks in 192 adult diabetic patients (136 men, 56 women; type 1/type 2: 90/102; age: 51.4±10.8 years; duration of diabetes: 15.3±9.1 years; body mass index: 27.9±4.6 kg/m2; HbA(1c): 8.5±1.5 %; actual blood pressure: 138±14/82±8 mmHg; serum creatinine: 94±20 μmol/I; x±SD). RESULTS - According to the urinary albumin excretion values, one third of patients (31.2%-30.7%-34.4%) were normoalbuminuric (<30 mg/24 hours), more than half of the patients (55.8%- 57.3%-53.6%) proved to be microalbuminuric: (30-300 mg/24 hours), while the remaining group of patients (13.0%-12.0%-12.0%) was macroalbuminuric (>300 mg/24 hours). Comparing the results of successive measurements good correlation was found between the same laboratory values (urinary albumin excretion: κ=0.64; κ=0.67; urinary albumin concentration: κ=0.60; κ=0.62; albumin to creatinine ratio: κ=0.54; κ=0.61; first vs. second and second vs. third measurements, respectively). The percentage of patients being in the same range of albuminuria (i.e. normo-, micro- or macroalbuminuria) at successive measurements was 79.7-81.2% with urinary albumin excretion values, 77.1-77.6% with urinary albumin concentration and 74.5-78.6% with albumin to creatinine ratio. Good correlations were found between urinary albumin excretion and urinary albumin concentration (κ=0.54; 0.54; 0 57) and nearly the same correlations were observed between urinary albumin excretion and albumin to creatinine ratio (κ=0.49; 0.47; 0.54) at different series. Using values of urinary albumin excretion for comparison at all measurements, 79.3% sensitivity and 69.5% specifity were found for urinary albumin concentration whereas 74.6% sensitivity and 68.8% specifity were documented for albumin to creatinine ratio. CONCLUSION - Beside the standard measurement of urinary albumin excretion in timed urine samples, the use of the more convenient morning urinary spot collection could also provide useful results (urinary albumin concentration or albumin to creatinine ratio) for detecting early renal involvement in diabetic patients.
|Translated title of the contribution||Practical aspects of screening for microalbuminuria in diabetic patients|
|Number of pages||7|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Aug 5 2000|
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