Practical aspects of chiral separations of pharmaceuticals by capillary electrophoresis I. Separation optimization

A. Guttman, Nelson Cooke

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Capillary electrophoresis employing chiral selectors has been shown to be a useful analytical method to separate enantiomers. In our model system hydroxypropyl-β-cyclodextrin was used as chiral selector for the separation of racemic propranolol. Results are presented regarding the effect of different operational variables such as buffer pH, concentration of chiral selector, applied electric field and temperature on the chiral separation. Based on the experimental data, the operational variables were optimized to attain maximum resolving power with minimal analysis time.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalJournal of Chromatography A
Volume680
Issue number1
DOIs
Publication statusPublished - Sep 30 1994

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Capillary electrophoresis
Cyclodextrins
Capillary Electrophoresis
Propranolol
Buffers
Temperature
Enantiomers
Optical resolving power
Pharmaceutical Preparations
Electric fields

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Practical aspects of chiral separations of pharmaceuticals by capillary electrophoresis I. Separation optimization. / Guttman, A.; Cooke, Nelson.

In: Journal of Chromatography A, Vol. 680, No. 1, 30.09.1994, p. 157-162.

Research output: Contribution to journalArticle

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