Practical aspects in chiral separation of pharmaceuticals by capillary electrophoresis. II. Quantitative separation of naproxen enantiomers

A. Guttman, Nelson Cooke

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In recent years, there has been considerable activity in the separation and characterization of optically active molecules. In this paper we report a new, improved and automated electrophoretic method for the separation of enantiomers in the form of high-performance capillary gel electrophoresis using hydroxypropyl-β-cyclodextrin as a chiral selector. Rapid, efficient separation of naproxen enantiomers is shown with very low detection limits and excellent detection linearity. The intra- and inter-day as well as intra- and inter-column migration time reproducibility was less than 2% R.S.D. Trace level enantiomeric contamination determination is also shown.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Chromatography A
Volume685
Issue number1
DOIs
Publication statusPublished - Nov 11 1994

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Capillary electrophoresis
Naproxen
Enantiomers
Cyclodextrins
Capillary Electrophoresis
Limit of Detection
Gels
Pharmaceutical Preparations
Electrophoresis
Contamination
Molecules

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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