PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function

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47 Citations (Scopus)

Abstract

In recent years it became apparent that PPARγ, besides being a key component of adipose tissue development and a target of insulin-sensitizing drugs, also has a role in immune cell differentiation and function. This receptor has been identified by us and others as a conductor of lipid handling in macrophages, and has roles also in inflammation control. Here we review recent advances on the role of this nuclear receptor in another key cell type of myeloid origin, dendritic cells (DCs). DCs are professional antigen-presenting cells having essential roles in antigen-uptake processing and presentation and in initiation of various forms of immune responses. It appears that PPARγ is expressed and is active in myeloid DCs and likely to be a regulator of DC function by altering antigen uptake, maturation, activation, migration, cytokine production, and lipid antigen presentation. Thus PPARγ is at the crossroads of lipid metabolism and innate immune response, and by studying its functions one has a unique opportunity to discern how these two seemingly distant fields (lipid metabolism and immune response) are interrelated. It is also possible that this receptor is a relevant target for pharmacological intervention in immune diseases such as chronic inflammation and autoimmune conditions.

Original languageEnglish
Title of host publicationNeuroendocrine and Immune Crosstalk
PublisherBlackwell Publishing Inc.
Pages207-218
Number of pages12
ISBN (Print)1573316237, 9781573316231
DOIs
Publication statusPublished - Nov 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1088
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • CD1
  • Dendritic cells
  • Innate immune response
  • Lipid metabolism
  • Nuclear hormone receptors
  • PPARγ
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Szatmari, I., Rajnavolgyi, E., & Nagy, L. (2006). PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function. In Neuroendocrine and Immune Crosstalk (pp. 207-218). (Annals of the New York Academy of Sciences; Vol. 1088). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1366.013