Potentiometric and spectroscopic studies on transition metal complexes of GlyLys(Gly) and Asp-ε-Lys

C. Kállay, K. Várnagy, I. Sóvágó, Daniele Sanna, Giovanni Micera

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Abstract

Copper(II), nickel(II) and zinc(II) complexes of the peptides GlyLys(Gly) and Asp-ε-Lys, containing the amide functions at the ε-amino groups of the lysyl residues were studied by potentiometric, UV-VIS and EPR spectroscopic methods. The stoichiometry of the major species formed in the copper(II)-GlyLys(Gly) system is [CuH-1L] and the EPR spectroscopic data indicate the existence of two isomeric forms of the complex. The nickel(II) and zinc(II)-GlyLys(Gly) systems have been characterised by the formation of stable [ML]+ complexes containing bis(NH2,CO) co-ordination and a macrochelate. Deprotonation and co-ordination of the amide groups were detected in the copper(II) and nickel(II) complexes. The co-ordination chemistry of Asp-ε-Lys is best described by the metal binding ability of the amino acid residues and it's high affinity for dimerisation. The stoichiometry of the dinuclear complexes can be given as [M2L2], containing only amino acid binding sites. Deprotonation and co-ordination of the amide functions were suggested only in the copper(II)- containing systems, resulting in the formation of the [Cu2H-2L2]2- dinuclear complex.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalJournal of the Chemical Society, Dalton Transactions
Volume2
Issue number1
Publication statusPublished - 2002

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Coordination Complexes
Transition metals
Copper
Nickel
Amides
Deprotonation
Stoichiometry
Paramagnetic resonance
Zinc
Amino Acids
Dimerization
Carbon Monoxide
Metals
Binding Sites
Peptides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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title = "Potentiometric and spectroscopic studies on transition metal complexes of GlyLys(Gly) and Asp-ε-Lys",
abstract = "Copper(II), nickel(II) and zinc(II) complexes of the peptides GlyLys(Gly) and Asp-ε-Lys, containing the amide functions at the ε-amino groups of the lysyl residues were studied by potentiometric, UV-VIS and EPR spectroscopic methods. The stoichiometry of the major species formed in the copper(II)-GlyLys(Gly) system is [CuH-1L] and the EPR spectroscopic data indicate the existence of two isomeric forms of the complex. The nickel(II) and zinc(II)-GlyLys(Gly) systems have been characterised by the formation of stable [ML]+ complexes containing bis(NH2,CO) co-ordination and a macrochelate. Deprotonation and co-ordination of the amide groups were detected in the copper(II) and nickel(II) complexes. The co-ordination chemistry of Asp-ε-Lys is best described by the metal binding ability of the amino acid residues and it's high affinity for dimerisation. The stoichiometry of the dinuclear complexes can be given as [M2L2], containing only amino acid binding sites. Deprotonation and co-ordination of the amide functions were suggested only in the copper(II)- containing systems, resulting in the formation of the [Cu2H-2L2]2- dinuclear complex.",
author = "C. K{\'a}llay and K. V{\'a}rnagy and I. S{\'o}v{\'a}g{\'o} and Daniele Sanna and Giovanni Micera",
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T1 - Potentiometric and spectroscopic studies on transition metal complexes of GlyLys(Gly) and Asp-ε-Lys

AU - Kállay, C.

AU - Várnagy, K.

AU - Sóvágó, I.

AU - Sanna, Daniele

AU - Micera, Giovanni

PY - 2002

Y1 - 2002

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