Potentiation of thermoregulatory and analygesic effects of morphine by calcium antagonists

George Benedek, Margit Szikszay

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Diltiazem, a calcium slow channel blocker, greatly potentiated and prolonged the antinociceptive effect of morphine in rats. Hypothermia, the primary thermoregulatory effect of morphine, was also potentiated. Verapamil, another calcium blocker elicited corresponding changes in the analgetic and thermoregulatory effects of morphine. These findings seem to be in concert with the suggestions that opiate effects on thermoregulation and nociception are exerted via modulation of calcium fluxes across neural membranes.

Original languageEnglish
Pages (from-to)1009-1018
Number of pages10
JournalPharmacological Research Communications
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 1984

ASJC Scopus subject areas

  • Pharmacology

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