Potentiation of the uterus-relaxing effects of β-adrenergic agonists with nifedipine: Studies on rats and the human myometrium

Judit Hajagos-Tth, Zsolt Kormnyos, G. Falkay, Attila Pl, Rbert Gspr

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. We investigated how progesterone and salmeterol modify the effect of nifedipine in an in vivo preterm birth model in rats, and how terbutaline and nifedipine modify the contractions of the isolated human myometrium. Design. Experimental animal and human myometrial studies. Sample. Twenty-four female SpragueDawley rats and 13 human uterine tissues sampled from cesarean section. Methods. Preterm birth was induced in SpragueDawley rats with a combination of mifepristone and prostaglandin-E2. The animals were treated with nifedipine or its combination with salmeterol and progesterone. Additionally, isolated human myometrial strips from cesarean sections were stimulated with oxytocin, and the inhibitory effects of nifedipine and terbutaline were studied. Results. Nifedipine delayed the preterm delivery in the rats, but its effect was tripled by the addition of β2-mimetics, or abolished after progesterone pretreatment. Synergism was observed in the relaxing effects of nifedipine and terbutaline on the isolated human myometrium. Conclusion. The action of nifedipine in delaying labor is impeded by progesterone. A combination of nifedipine and β2-agonists should be considered for the treatment or prevention of preterm birth.

Original languageEnglish
Pages (from-to)1284-1289
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume89
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Adrenergic Agonists
Myometrium
Nifedipine
Uterus
Terbutaline
Progesterone
Premature Birth
Cesarean Section
Mifepristone
Oxytocin
Dinoprostone

Keywords

  • β2-Mimetics
  • Nifedipine
  • Preterm
  • Progesterone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Potentiation of the uterus-relaxing effects of β-adrenergic agonists with nifedipine : Studies on rats and the human myometrium. / Hajagos-Tth, Judit; Kormnyos, Zsolt; Falkay, G.; Pl, Attila; Gspr, Rbert.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 89, No. 10, 10.2010, p. 1284-1289.

Research output: Contribution to journalArticle

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