Potentiation of the antitumor action of 5-fluorouracil with 5-ethyl-2'-deoxyuridine in human colorectal tumor xenografts

L. Kopper, E. Magyarosy, A. Jeney, K. Lapis, A. Szabolcs, L. Otvös

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The tumor growth inhibitory effect of 5-ethyl-2'-deoxyuridine (EUdR) in combination with 5-fluorouracil (5-FU) has been studied on four human colorectal xenograft lines. In all lines the EUdR pretreatment potentiated the effect of 5-FU presumably due to the increased incorporation pf 5-FU into RNA via elevated intracellular thymidine concentration and decreased rate of 5-FU catabolism.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalOncology
Volume41
Issue number3
DOIs
Publication statusPublished - Jan 1 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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