Potentiation of non-specific host defence by polysaccharides like lentinan: Possible mechanisms

J. Fachet, G. Abel, S. Jusupova, S. Imre, E. Katona, J. Erdel, J. Szöllősi, G. Chihara

Research output: Contribution to journalArticle

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Abstract

Polyglucan-type polysaccharides have been proved to have strong antitumour effects, modulated by genetic factors, in different inbred and H-2 congenic strains of mice. One of the most purified and effective β-1,3-glucan polysaccharides, lentinan (L) was found to inhibit the development of fibrosarcoma (A/Ph.M.C.S1) in a murine syngeneic tumour-host system. Under these circumstances, lentinan was able to increase the antibody responses and the delayed-type hypersensitivity reactions, and to decrease susceptibility to anaphylactic shock in mice. Further detailed studies revealed a significant increase in endocytotic activity (pinocytosis and phagocytosis) and the chemiluminescence of macrophages on treatment with L, especially if it were applied in an opsonized form. The plasma level of a 'multifunctional' molecule, fibronectin (one of the opsonizing factors), was found to be increased in tumour-bearing mice, but it was decreased after treatment with L, although the same L treatment alone did not affect it. In general, superoxide dismutase (CuZnSOD) activity in the liver was found to be increased, while lipid peroxidation (LP) was shown to be decreased due to treatment with L in different inbred and H-2 congenic strains of mice. According to the modulation of the different types of immune responses by treatment with L, the stimulation of the non-specific host resistance (like activation of Mφs) might have a unique and decisive role in the increase of host defence against tumours.

Original languageEnglish
Pages (from-to)167-176
Number of pages10
JournalInternational Journal of Immunotherapy
Volume5
Issue number4
Publication statusPublished - 1989

Fingerprint

Lentinan
Congenic Mice
Polysaccharides
Pinocytosis
Neoplasms
Glucans
Fibrosarcoma
Delayed Hypersensitivity
Anaphylaxis
Luminescence
Fibronectins
Phagocytosis
Lipid Peroxidation
Superoxide Dismutase
Antibody Formation
Macrophages
Liver

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Fachet, J., Abel, G., Jusupova, S., Imre, S., Katona, E., Erdel, J., ... Chihara, G. (1989). Potentiation of non-specific host defence by polysaccharides like lentinan: Possible mechanisms. International Journal of Immunotherapy, 5(4), 167-176.

Potentiation of non-specific host defence by polysaccharides like lentinan : Possible mechanisms. / Fachet, J.; Abel, G.; Jusupova, S.; Imre, S.; Katona, E.; Erdel, J.; Szöllősi, J.; Chihara, G.

In: International Journal of Immunotherapy, Vol. 5, No. 4, 1989, p. 167-176.

Research output: Contribution to journalArticle

Fachet, J. ; Abel, G. ; Jusupova, S. ; Imre, S. ; Katona, E. ; Erdel, J. ; Szöllősi, J. ; Chihara, G. / Potentiation of non-specific host defence by polysaccharides like lentinan : Possible mechanisms. In: International Journal of Immunotherapy. 1989 ; Vol. 5, No. 4. pp. 167-176.
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