Potentiation of ionophorous anticoccidials with dihydroquinolines: Battery trials against Eimeria tenella in chickens

István Varga, Péter Laczay, József Lehel, Zsuzsa Móra, Attila Romváry, Jenõ Fekete

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Seven battery tests, employing a total of 1344 Hybro cockerels, were conducted in order to study the interaction between ionophorous anticoccidials and a new dihydroquinoline-type antioxidant known as duokvin. A significant, non-selective, toxic interaction was established, resulting in growth depression and improved anticoccidial efficacy against Eimeria tenella and E. mitis in these chickens. The duokvin itself showed no appreciable activity against the coccidia. The adverse effects of the interaction were eliminated, and the anticoccidial efficacy of the approved levels of ionophores was maintained, when the dietary levels of monovalent cation ionophorous monensin, salinomycin and narasin were reduced to approximately 12% in the presence of 120p.p.m. duokvin. No adverse effects on the growth of chickens appeared in the combination with maduramicin, yet the enhancement of anticoccidial activity allowed an approx. 50% reduction of this ionophore as well.

Original languageEnglish
Pages (from-to)689-694
Number of pages6
JournalInternational Journal for Parasitology
Volume24
Issue number5
DOIs
Publication statusPublished - Aug 1994

Keywords

  • Eimeria tenella
  • anticoccidials
  • antioxidant
  • chicken
  • coccidiosis
  • dihydroquinoline
  • duokvin
  • maduramicin
  • monensin
  • narasin
  • potentiation of ionophores
  • salinomycin

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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