Potentiated hypnotic action with a combination of fentanyl, a calcium channel blocker and an α2‐agonist in rats

Gy Horváth, M. Szikszay, Gy Benedek

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An investigation was made of the hypnotic‐anaesthetic effects in rats of subcutaneous coadministration of fentanyl (25–100 μg˙kg‐1), clonidine (100–300 μg˙kg‐1) and verapamil (1–5 mg˙kg‐1). Hypnotic‐anaesthetic efficacy was assessed via loss of the righting reflex. In the doses used, none of the three drugs alone was associated with appreciable hypnotic‐anaesthetic effects. Coadministration of fentanyl and clonidine resulted in a dose‐related enhancement of the anaesthetic potency, without change in the duration of hypnotic action. Verapamil coadministration failed to increase the anaesthetic efficacy of binary combinations of fentanyl and clonidine, but a marked prolongation of the duration of hypnotic action was observed (P<0.001). These results suggest the existence of unreported interactions between these three drugs in the production of hypnotic‐anaesthetic action in rats.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Issue number2
Publication statusPublished - Feb 1992



  • Analgesics
  • anesthesia
  • calcium channel blockers
  • clonidine
  • fentanyl
  • verapamil
  • α ‐adrenoceptor agonists

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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