Potentiated hypnotic action with a combination of fentanyl, a calcium channel blocker and an α2-agonist in rats

G. Horváth, M. Szikszay, G. Benedek

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An investigation was made of the hypnotic-anaesthetic effects in rats of subcutaneous coadministration of fentanyl (25-100 μg·kg-1), clonidine (100-300 μg·kg-1) and verapamil (1-5 mg·kg-1). Hypnotic-anaesthetic efficacy was assessed via loss of the righting reflex. In the doses used, none of the three drugs alone was associated with appreciable hypnotic-anaesthetic effects. Coadministration of fentanyl and clonidine resulted in a dose-related enhancement of the anaesthetic potency, without change in the duration of hypnotic action. Verapamil coadministration failed to increase the anaesthetic efficacy of binary combinations of fentanyl and clonidine, but a marked prolongation of the duration of hypnotic action was observed (P <0.001). These results suggest the existence of unreported interactions between these three drugs in the production of hypnotic-anaesthetic action in rats.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume36
Issue number2
Publication statusPublished - 1992

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Calcium Channel Blockers
Fentanyl
Hypnotics and Sedatives
Anesthetics
Clonidine
Verapamil
Righting Reflex
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

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AU - Benedek, G.

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