Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs

T. Tuboly, É Nagy, J. B. Derbyshire

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Four viruses were compared for their ability to induce an intestinal antibody response in piglets. Antibodies were not detected in response to oral vaccination with either fowlpox virus or a baculovirus (BV). Simultaneous oral dosing and parenteral inoculation with high concentrations of BV in an oil emulsion adjuvant induced high levels of circulating virus neutralising (VN) antibodies, and also low levels of intestinal antibodies when booster doses of virus were given. In response to oral vaccination with swinepox virus (SPV), low levels of circulating and intestinal VN antibodies, and higher titres of antibodies reactive in an enzyme immunoassay, including intestinal antibodies of the IgA class, were detected. Oral vaccination with porcine adenovirus type 3 (PAV-3) stimulated both circulating and intestinal VN antibodies, and IgA antibodies were demonstrated in the intestinal contents. It was concluded that SPV and PAV-3 might be suitable vectors for the expression of genes encoding the protective antigens of porcine enteric viruses.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalResearch in Veterinary Science
Volume54
Issue number3
DOIs
Publication statusPublished - 1993

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Viral Antigens
viral antigens
Antibody Formation
Swine
Suipoxvirus
Porcine Adenoviruses
Viruses
oral vaccination
Neutralizing Antibodies
swine
antibodies
Swinepox virus
viruses
neutralizing antibodies
Vaccination
Antibodies
Baculoviridae
Immunoglobulin A
Adenoviridae
Fowlpox virus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs. / Tuboly, T.; Nagy, É; Derbyshire, J. B.

In: Research in Veterinary Science, Vol. 54, No. 3, 1993, p. 345-350.

Research output: Contribution to journalArticle

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