Potential significance of antiestrogen therapy in the development of bisphosphonate related osteonecrosis of the jaw

Mihaly Vaszilko, Evelin Kovacs, Laszlo Restar, Bernadett Balla, Krisztina Cseplo, Janos Kosa, Peter Lakatos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Conclusion The dominance of the female gender among BRONJ patients as well as our new findings related to antiestrogen therapy of breast cancer raise the possibility that estrogen deficiency might be a newly discovered risk factor for BRONJ.

Objectives There are known risk factors and established treatment protocols for bisphosphonate-related osteonecrosis of the jaw (BRONJ), but it remains a difficult disease to treat, with the risk of relapses. This study investigates whether or not there is a relationship between antiestrogen therapy and BRONJ. Patients and methods In our prospective study, we followed up 93 patients with BRONJ who were seen at our clinic between 2006 and 2011.

Results We found that breast cancer patients had a significantly worse prognosis than patients with other underlying illnesses (p < 0.01), which might indicate the role of antiestrogen therapy (p < 0.001) as a causative factor.

Original languageEnglish
Pages (from-to)1932-1936
Number of pages5
JournalJournal of Cranio-Maxillofacial Surgery
Volume42
Issue number8
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Antiestrogen therapy
  • Bisphosphonate
  • Breast cancer
  • Estrogen deficiency
  • Jaw
  • Osteonecrosis

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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