Az ösztrogének lehetséges szerepe a vastagbéldaganatok kialakulásában

Translated title of the contribution: Potential role of estrogens in colorectal tumour development

Leiszter Katalin, Galamb Orsolya, Kalmár Alexandra, Zsigrai Sára, Valcz Gábor, Szigeti Krisztina Andrea, Barták Barbara Kinga, Nagy Zsófia Brigitta, Dank Magdolna, Liposits Zsolt, Igaz Péter, Tulassay Zsolt, Molnár Béla

Research output: Contribution to journalArticle

Abstract

Colorectal cancer (CRC) is one of the most common types of cancers worldwide. The incidence of sporadic CRC is lower in individuals below 50 years and increases with age, furthermore, it shows typical clinical, macroscopic and molecular differences between females and males. According to the results of epidemiological and molecular biology studies, the estradiol-regulating signaling pathway plays an important role in the development and prognosis of CRC, predominantly through estrogen receptor beta (ERβ), which is dominant in the colonic epithelium. Estradiol has multiple gastrointestinal effects, which were confirmed by in vitro and in vivo studies on histologically intact and cancerous cells as well. In contrast to estrogen receptor alpha (ERα), the activation of ERβ inhibits cell proliferation and enhances apoptosis, nevertheless, the expression of estrogen receptor beta can change both during physiological ageing and in colorectal disorders. The ERβ-mediated antitumour effects of estradiol may be exerted through inhibition of cell proliferation, stimulation of apoptosis, inhibition of metastasis formation and its anti-inflammatory activity. Based on the results of cell culture and animal studies, selective modulators of estrogen receptor beta (selective estrogen receptor modulator [SERM]) and phytoestrogens can be new, additional therapeutic options in the treatment of colorectal diseases characterized by chronic inflammation and uncontrolled cell proliferation.

Translated title of the contributionPotential role of estrogens in colorectal tumour development
Original languageHungarian
Pages (from-to)532-543
Number of pages12
JournalOrvosi hetilap
Volume161
Issue number14
DOIs
Publication statusPublished - Jan 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Katalin, L., Orsolya, G., Alexandra, K., Sára, Z., Gábor, V., Andrea, S. K., Kinga, B. B., Brigitta, N. Z., Magdolna, D., Zsolt, L., Péter, I., Zsolt, T., & Béla, M. (2020). Az ösztrogének lehetséges szerepe a vastagbéldaganatok kialakulásában. Orvosi hetilap, 161(14), 532-543. https://doi.org/10.1556/650.2020.31674