Potential risk factors of blood coagulation and fibrinolysis in the development of stroke

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Abstract

44 young stroke patiens (under age 50) were included in the study, who possessed no known underlying disorder (arteriosclerosis, atrial thrombi etc.). Our goal was to evaluate potential causes that might have precipitated the disorder. We tested haemostasis abnormalities which can cause thrombosis: antithrombin III activity by chromogenic assay, protein C, and protein S activities both by clotting method and activated protein C resistance by APTT based clotting assay. Levels of fibrinolytic factors were also measured: PAI-1 level by ELISA method and α2 antiplasmin activity. Because lipoprotein (a) has extensive structural homology with plasminogen and competes with plasminogen receptor, thereby reducing plasmin generation and causing thrombosis, we measured lipoprotein (a) level by ELISA method. Our results showed that there were 3 patiens with decreased AT- III activity, 4 patients with protein C, 5 with protein S deficiency and 4 had activated protein C resistance. Increase in lipoprotein (a) level was found in 11 patients out of 32 examined and PAI-1 level was higher than reference limit in 17 Patients out of 44 examined. 10 patients had normal values for all parameters tested and 11 patients had at least 3 identifiable risk factors of thrombosis. Based on our findings we conclude that the impairment of fibrinolysis seems to at least as prevalent in young patients with ischémie stroke, as deficiencies of inhibitors or APC resistance.

Original languageEnglish
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 3
Publication statusPublished - Dec 1 1996

ASJC Scopus subject areas

  • Hematology

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