A protonpumpagátló kezelés eredménytelenségének okai gastrooesophagealis refluxbetegségben

Translated title of the contribution: Potential reasons for proton pump inhibitor failure in the treatment of gastroesophageal reflux disease

Márk Juhász, Z. Tulassay

Research output: Contribution to journalArticle

Abstract

The introduction of proton pump inhibitors (PPI) has facilitated the successful management of patients with gastroesophageal reflux disease (GERD). In a minor, but still relevant proportion of patients with GERD-like symptoms, PPI therapy has also proved to be ineffective. In such cases, the first question to be answered is if the symptoms and complaints are related to GERD indeed, or another disorder should be searched for. If GERD is still the most likely diagnosis, patients' compliance should be thoroughly investigated before any further diagnostic and therapeutic measure is taken. If PPI failure is not a result of inadequate management of GERD, there are several other disorders to be ruled out. In our review, we summarize the most important differential diagnostic issues of PPI failure.

Original languageHungarian
Pages (from-to)1881-1888
Number of pages8
JournalOrvosi Hetilap
Volume149
Issue number40
DOIs
Publication statusPublished - Oct 5 2008

Fingerprint

Proton Pump Inhibitors
Gastroesophageal Reflux
Treatment Failure
Patient Compliance
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A protonpumpagátló kezelés eredménytelenségének okai gastrooesophagealis refluxbetegségben. / Juhász, Márk; Tulassay, Z.

In: Orvosi Hetilap, Vol. 149, No. 40, 05.10.2008, p. 1881-1888.

Research output: Contribution to journalArticle

@article{c66c2389dda44731a628f148b42bd5e7,
title = "A protonpumpag{\'a}tl{\'o} kezel{\'e}s eredm{\'e}nytelens{\'e}g{\'e}nek okai gastrooesophagealis refluxbetegs{\'e}gben",
abstract = "The introduction of proton pump inhibitors (PPI) has facilitated the successful management of patients with gastroesophageal reflux disease (GERD). In a minor, but still relevant proportion of patients with GERD-like symptoms, PPI therapy has also proved to be ineffective. In such cases, the first question to be answered is if the symptoms and complaints are related to GERD indeed, or another disorder should be searched for. If GERD is still the most likely diagnosis, patients' compliance should be thoroughly investigated before any further diagnostic and therapeutic measure is taken. If PPI failure is not a result of inadequate management of GERD, there are several other disorders to be ruled out. In our review, we summarize the most important differential diagnostic issues of PPI failure.",
keywords = "Gastroesophageal reflux disease, PPI failure, Proton pump inhibitor",
author = "M{\'a}rk Juh{\'a}sz and Z. Tulassay",
year = "2008",
month = "10",
day = "5",
doi = "10.1556/OH.2008.28438",
language = "Hungarian",
volume = "149",
pages = "1881--1888",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "40",

}

TY - JOUR

T1 - A protonpumpagátló kezelés eredménytelenségének okai gastrooesophagealis refluxbetegségben

AU - Juhász, Márk

AU - Tulassay, Z.

PY - 2008/10/5

Y1 - 2008/10/5

N2 - The introduction of proton pump inhibitors (PPI) has facilitated the successful management of patients with gastroesophageal reflux disease (GERD). In a minor, but still relevant proportion of patients with GERD-like symptoms, PPI therapy has also proved to be ineffective. In such cases, the first question to be answered is if the symptoms and complaints are related to GERD indeed, or another disorder should be searched for. If GERD is still the most likely diagnosis, patients' compliance should be thoroughly investigated before any further diagnostic and therapeutic measure is taken. If PPI failure is not a result of inadequate management of GERD, there are several other disorders to be ruled out. In our review, we summarize the most important differential diagnostic issues of PPI failure.

AB - The introduction of proton pump inhibitors (PPI) has facilitated the successful management of patients with gastroesophageal reflux disease (GERD). In a minor, but still relevant proportion of patients with GERD-like symptoms, PPI therapy has also proved to be ineffective. In such cases, the first question to be answered is if the symptoms and complaints are related to GERD indeed, or another disorder should be searched for. If GERD is still the most likely diagnosis, patients' compliance should be thoroughly investigated before any further diagnostic and therapeutic measure is taken. If PPI failure is not a result of inadequate management of GERD, there are several other disorders to be ruled out. In our review, we summarize the most important differential diagnostic issues of PPI failure.

KW - Gastroesophageal reflux disease

KW - PPI failure

KW - Proton pump inhibitor

UR - http://www.scopus.com/inward/record.url?scp=55049085020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55049085020&partnerID=8YFLogxK

U2 - 10.1556/OH.2008.28438

DO - 10.1556/OH.2008.28438

M3 - Article

C2 - 18815107

AN - SCOPUS:55049085020

VL - 149

SP - 1881

EP - 1888

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 40

ER -