Potential benefits of discrete-time controller-based treatments over protocol-based cancer therapies

Johanna Sápi, Dániel András Drexler, L. Kovács

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In medical practice, the effectiveness of fighting cancer is not only determined by the composition of the used drug, but determined by the administration method as well. As a result, having drugs with a suitable action profile is just a promising beginning, but without appropriate delivery methods, the therapy still can be ineffective. Finding the optimal biologic dose is an empirical process in medical practice; however, using controllers, an automated optimal administration can be determined. In this paper, we evaluate the effectiveness of different drug delivery protocols; using in silico simulations (like bolus doses, low-dose metronomic regimen and continuous infusion therapy). In addition, we compare these results with discrete-time controller-based treatments containing state feedback, setpoint control, actual state observer and load estimation.

Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalActa Polytechnica Hungarica
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Controllers
State feedback
Drug delivery
Feedback control
Chemical analysis

Keywords

  • Actual state observer
  • Antiangiogenic therapy
  • Bolus dose
  • Continuous infusion therapy
  • Discrete-time control
  • Load estimation
  • Low-dose metronomic regimen
  • Maximum tolerated dose
  • Optimal biologic dose
  • Setpoint control
  • State feedback

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Potential benefits of discrete-time controller-based treatments over protocol-based cancer therapies. / Sápi, Johanna; Drexler, Dániel András; Kovács, L.

In: Acta Polytechnica Hungarica, Vol. 14, No. 1, 01.01.2017, p. 11-23.

Research output: Contribution to journalArticle

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