Potent inhibitory GABAB receptors in stimulated guinea-pig taenia coli

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Abstract

γ-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 μM) and (-)-baclofen (IC50 = 4.5 μM) but not 10-4 M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10-5 M (1S, 9R)-bicuculline methiodide was not specific for GABA agonists. The results suggest that the GABA receptors involved were of type B.

Original languageEnglish
Pages (from-to)1623-1627
Number of pages5
JournalNeuropharmacology
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 1987

Keywords

  • (-)-baclofen
  • (1S
  • 9R)-bicuculline methiodide
  • GABA receptors
  • guinea-pig taenia-coli
  • muscimol

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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