Potassium movements in relation to synaptosomal morphology

A. Csillág, F. Hajos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The uptake of K+ by rat cortical synaptosomes was followed using a K+-selective membrane electrode. A parallel morphological study was carried out based on the previous description of two different configurations of incubated synaptosomes (S and M configurations). Synaptosomes were able to take up K+ against a concentration gradient: The average amount of cation taken up at equilibrium was 42.3 ± 3.1 (7) nmol-mg protein. Following K+ uptake the particles displayed a configuration corresponding to that of intact nerve endings in situ ('M-configuration'). In conditions where the uptake of K+ was inhibited or a net loss was elicited the development of M-configuration was prevented. Agents which affected both the plasma membrane Na+-K+ transport system and mitochondrial energy conservation brought about the 'S-configuration' characteristic of unincubated synaptosomes, whereas in conditions where the plasma membrane transport system was preferentially inhibited, transitional forms were found. It was concluded that the S to M transition found in incubated synaptosomes is primarily associated with the inward movement of potassium.

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalJournal of Neurochemistry
Volume34
Issue number3
Publication statusPublished - 1980

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Synaptosomes
Cell membranes
Potassium
Cations
Rats
Energy conservation
Membranes
Electrodes
Cell Membrane
Nerve Endings
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Potassium movements in relation to synaptosomal morphology. / Csillág, A.; Hajos, F.

In: Journal of Neurochemistry, Vol. 34, No. 3, 1980, p. 495-503.

Research output: Contribution to journalArticle

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