Potassium-induced histamine release from mast cells and its inhibition by ketotifen

A. Németh, P. Magyar, R. Herceg, Z. Huszti

Research output: Contribution to journalArticle

13 Citations (Scopus)


Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 m M in the absence of extracellular Ca2+. Potassium concentrations greater than 150 m M produced less histamine release. The release was energy-dependent and was complete within one minute. The histamine liberating effect of KCl could be inhibited by NaCl and by preincubation with ketotifen. The monovalent cations, Rb+ and Cs+ also evoked histamine release, whereas Na+ and Li+ were ineffective.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalAgents and Actions
Issue number3-4
Publication statusPublished - Apr 1 1987

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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