Poszttranszplantációs lymphoproliferativ betegség gyermekkorban

Anita Stréhn, László Szonyi, Gergely Kriván, Lajos Kovács, G. Reusz, Attila Szabó, Imre Rényi, Gábor Kovács, Antal Dezsofi

Research output: Contribution to journalArticle

Abstract

Introduction: Among possible complications of transplantation the post-transplant lymphoproliferative disease due to immunosuppressive therapy is of paramount importance. In most cases the direct modulating effect of Epstein-Barr virus on immune cells can be documented. Aim: The aim of the authors was to evaluate the incidence os post-transplant lymphoproliferative diseases in pediatric transplant patients in Hungary. Method: The study group included kidney, liver and lung transplant children followed up at the 1st Department of Pediatrics, Semmelweis University, Budapest and stem cell transplant children at Szent László Hospital, Budapest. Data were collected from 78 kidney, 109 liver and 17 lung transplant children as well as from 243 children who underwent allogenic stem cell transplantation. Results: Between 1998 and 2012, 13 children developed post-transplant lymphoproliferative disorder (8 solid organ transplanted and 5 stem cell transplanted children). The diagnosis was based on histological findings in all cases. Mortality was 3 out of the 8 solid organ transplant children and 4 out of the 5 stem cell transplant children. The highest incidence was observed among lung transplant children (17.6%). Conclusions: These data indicate that post-transplant lymphoproliferative disease is a rare but devastating complication of transplantation in children. The most important therapeutic approaches are reduction of immunosuppressive therapy, chemotherapy and rituximab. Early diagnosis may improve clinical outcome and, therefore, routine polymerase chain reaction screening for Epstein-Barr virus of high risk patients is recommended. Orv. Hetil., 2014, 155(8),.

Original languageHungarian
Pages (from-to)313-318
Number of pages6
JournalOrvosi Hetilap
Volume155
Issue number8
DOIs
Publication statusPublished - Feb 1 2014

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stréhn, A., Szonyi, L., Kriván, G., Kovács, L., Reusz, G., Szabó, A., ... Dezsofi, A. (2014). Poszttranszplantációs lymphoproliferativ betegség gyermekkorban. Orvosi Hetilap, 155(8), 313-318. https://doi.org/10.1556/OH.2014.29796

Poszttranszplantációs lymphoproliferativ betegség gyermekkorban. / Stréhn, Anita; Szonyi, László; Kriván, Gergely; Kovács, Lajos; Reusz, G.; Szabó, Attila; Rényi, Imre; Kovács, Gábor; Dezsofi, Antal.

In: Orvosi Hetilap, Vol. 155, No. 8, 01.02.2014, p. 313-318.

Research output: Contribution to journalArticle

Stréhn, A, Szonyi, L, Kriván, G, Kovács, L, Reusz, G, Szabó, A, Rényi, I, Kovács, G & Dezsofi, A 2014, 'Poszttranszplantációs lymphoproliferativ betegség gyermekkorban', Orvosi Hetilap, vol. 155, no. 8, pp. 313-318. https://doi.org/10.1556/OH.2014.29796
Stréhn A, Szonyi L, Kriván G, Kovács L, Reusz G, Szabó A et al. Poszttranszplantációs lymphoproliferativ betegség gyermekkorban. Orvosi Hetilap. 2014 Feb 1;155(8):313-318. https://doi.org/10.1556/OH.2014.29796
Stréhn, Anita ; Szonyi, László ; Kriván, Gergely ; Kovács, Lajos ; Reusz, G. ; Szabó, Attila ; Rényi, Imre ; Kovács, Gábor ; Dezsofi, Antal. / Poszttranszplantációs lymphoproliferativ betegség gyermekkorban. In: Orvosi Hetilap. 2014 ; Vol. 155, No. 8. pp. 313-318.
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abstract = "Introduction: Among possible complications of transplantation the post-transplant lymphoproliferative disease due to immunosuppressive therapy is of paramount importance. In most cases the direct modulating effect of Epstein-Barr virus on immune cells can be documented. Aim: The aim of the authors was to evaluate the incidence os post-transplant lymphoproliferative diseases in pediatric transplant patients in Hungary. Method: The study group included kidney, liver and lung transplant children followed up at the 1st Department of Pediatrics, Semmelweis University, Budapest and stem cell transplant children at Szent L{\'a}szl{\'o} Hospital, Budapest. Data were collected from 78 kidney, 109 liver and 17 lung transplant children as well as from 243 children who underwent allogenic stem cell transplantation. Results: Between 1998 and 2012, 13 children developed post-transplant lymphoproliferative disorder (8 solid organ transplanted and 5 stem cell transplanted children). The diagnosis was based on histological findings in all cases. Mortality was 3 out of the 8 solid organ transplant children and 4 out of the 5 stem cell transplant children. The highest incidence was observed among lung transplant children (17.6{\%}). Conclusions: These data indicate that post-transplant lymphoproliferative disease is a rare but devastating complication of transplantation in children. The most important therapeutic approaches are reduction of immunosuppressive therapy, chemotherapy and rituximab. Early diagnosis may improve clinical outcome and, therefore, routine polymerase chain reaction screening for Epstein-Barr virus of high risk patients is recommended. Orv. Hetil., 2014, 155(8),.",
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AU - Szonyi, László

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AU - Kovács, Lajos

AU - Reusz, G.

AU - Szabó, Attila

AU - Rényi, Imre

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AB - Introduction: Among possible complications of transplantation the post-transplant lymphoproliferative disease due to immunosuppressive therapy is of paramount importance. In most cases the direct modulating effect of Epstein-Barr virus on immune cells can be documented. Aim: The aim of the authors was to evaluate the incidence os post-transplant lymphoproliferative diseases in pediatric transplant patients in Hungary. Method: The study group included kidney, liver and lung transplant children followed up at the 1st Department of Pediatrics, Semmelweis University, Budapest and stem cell transplant children at Szent László Hospital, Budapest. Data were collected from 78 kidney, 109 liver and 17 lung transplant children as well as from 243 children who underwent allogenic stem cell transplantation. Results: Between 1998 and 2012, 13 children developed post-transplant lymphoproliferative disorder (8 solid organ transplanted and 5 stem cell transplanted children). The diagnosis was based on histological findings in all cases. Mortality was 3 out of the 8 solid organ transplant children and 4 out of the 5 stem cell transplant children. The highest incidence was observed among lung transplant children (17.6%). Conclusions: These data indicate that post-transplant lymphoproliferative disease is a rare but devastating complication of transplantation in children. The most important therapeutic approaches are reduction of immunosuppressive therapy, chemotherapy and rituximab. Early diagnosis may improve clinical outcome and, therefore, routine polymerase chain reaction screening for Epstein-Barr virus of high risk patients is recommended. Orv. Hetil., 2014, 155(8),.

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