Proteins are subject to continuous reversible and irreversible modifications. These posttranslational modifications directly influence the stability and/or the function of proteins. Aging results in an increased half-life of proteins, which is associated with enhanced oxidative modifications of amino acid residues. Lysine residues are carbonylated, acetylated, and ubiquitinated, and cross talk between these modifications is crucial for the fate of proteins.
|Title of host publication||Physical Activity, Exercise, Sedentary Behavior and Health|
|Number of pages||5|
|Publication status||Published - Jan 1 2015|
- Reactive oxygen species
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