Postoperative treatment of glioblastoma with BNCT at the Petten irradiation facility (EORTC Protocol 11961)

Katalin Hideghéty, Wolfgang Sauerwein, Klaus Haselsberger, Frank Grochulla, Heinz Fankhauser, Raymond Moss, René Huiskamp, Detlef Gabel, Martin De Vries

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24 Citations (Scopus)


The boron neutron capture therapy is based on the reaction occurring between the isotope 10B and thermal neutrons. A low energy neutron is captured by the nucleus and it disintegrates into two densly ionising particles, Li nucleus and He nucleus (α particle), with high biological effectiveness. On the basis of comprehensive preclinical investigations in the frame of the European Collaboration with Na2B12H11SH (BSH), as boron delivery agent, the first European phase I, clinical trial was designed at the only available epithermal beam in Europe, at the High Flux Reactor, Petten, in the Netherland. The goal of this study is to establish the safe BNCT dose for cranial tumors under defined conditions. BNCT is applied as postoperative radiotherapy in 4 fractions, after removal of the tumor for a group of patients suffering from glioblastoma, who would have no benefit from conventional treatment, but have sufficient life expectancy to detect late radiation morbidity due to BNCT. The starting dose is set at 80% of the dose where neurological effects occurred in preclinical large animal experiments following a single fraction. The radiation dose will be escalated, by constant boron concentration in blood, in 4 steps for cohorts of ten patients, after an observation period of at least 6 months after the end of BNCT of the last patient of a cohort. The adverse events on healthy tissues due to BSH and due to the radiotherapy will be analysed in order to establish the maximal tolerated dose and dose limiting toxicity. Besides of the primary aim of this study the survival will be recorded. The first patient was treated in October 1997, and further four patients have been irradiated to date. The protocol design proved to be well applicable, establishing the basis for scientific evaluation, for performance of safe patient treatment in a very complex situation and for opening the possibility to perform further clinical research work on BNCT.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalStrahlentherapie und Onkologie
Issue numberSUPPL. 2
Publication statusPublished - Jun 1999


  • BNCT
  • BSH
  • Glioblastoma
  • Phase I study

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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  • Cite this

    Hideghéty, K., Sauerwein, W., Haselsberger, K., Grochulla, F., Fankhauser, H., Moss, R., Huiskamp, R., Gabel, D., & De Vries, M. (1999). Postoperative treatment of glioblastoma with BNCT at the Petten irradiation facility (EORTC Protocol 11961). Strahlentherapie und Onkologie, 175(SUPPL. 2), 111-114.