Herpes simplex keratitisekben végzett perforáló keratoplasztika posztoperatív terápiája

Translated title of the contribution: Postoperative therapy of penetrating keratoplasty in herpes simplex keratitis

I. Süveges, Ágnes Füst, László Imre

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Keratitis due to herpes simplex infection is a common cause of corneal damage resulting in impaired vision. Aim: The aim of this study was to assess the outcome of penetrating keratoplasties in patients treated with systemic antiviral and immunosuppressive drugs. Method: The authors retrospectively analysed data of 12 patients who underwent penetrating keratoplasty. The average age at onset of the first keratitis preceding surgery was 18 years (between 5 and 40 years). The indication for surgery in 9 cases was to improve vision and in 3 patient to prevent corneal perforation. Nine patients were given both acyclovir and mycophenolate mofetil, as anti-viral agent and immunosuppressive treatment, respectively. Two patients were treated with anti-viral agent only while one patient received no systemic therapy. The average follow-up time was 53.1 months (between 16 and 84 months). Results: Of the 9 patients who underwent surgery for improving vision, 8 patients had transparent grafts during follow up without vascularization. All eight patients had been treated with acyclovir and mycophenolate mofetil. In one patient who had no systemic treatment recurrence and graft rejection was observed. Only one of the surgeries performed in acute stage of inflammation resulted in a properly healed transparent graft without recurrence and rejection. In this patient acyclivir and mycophenolate mofetil therapy had been given previously. In two cases the preventive - full or partial - systemic treatment had no effect. The visual acuity improved in all cases. In three patients visual acuity was influenced by some other factors as well. Conclusions: The systemic acyclovir and mycophenolat mofetil therapy is fairly successful in perforating keratoplasty due to herpes simplex infection. Acyclovir decreases the risk of recurrence, while mycophenolate mofetil may prevent graft rejection. The timing of surgery is decisive; it leads to better results when performed in a scarred, noninflammatory state. Orv. Hetil., 2013, 154(52), 2065-2070.

Original languageHungarian
Pages (from-to)2065-2070
Number of pages6
JournalOrvosi Hetilap
Volume154
Issue number52
DOIs
Publication statusPublished - Dec 1 2013

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Herpetic Keratitis
Penetrating Keratoplasty
Mycophenolic Acid
Acyclovir
Therapeutics
Herpes Simplex
Keratitis
Graft Rejection
Immunosuppressive Agents
Recurrence
Visual Acuity
Corneal Perforation
Patient Acuity
Transplants
Corneal Transplantation
Infection
Age of Onset
Antiviral Agents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Herpes simplex keratitisekben végzett perforáló keratoplasztika posztoperatív terápiája. / Süveges, I.; Füst, Ágnes; Imre, László.

In: Orvosi Hetilap, Vol. 154, No. 52, 01.12.2013, p. 2065-2070.

Research output: Contribution to journalArticle

Süveges, I. ; Füst, Ágnes ; Imre, László. / Herpes simplex keratitisekben végzett perforáló keratoplasztika posztoperatív terápiája. In: Orvosi Hetilap. 2013 ; Vol. 154, No. 52. pp. 2065-2070.
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abstract = "Introduction: Keratitis due to herpes simplex infection is a common cause of corneal damage resulting in impaired vision. Aim: The aim of this study was to assess the outcome of penetrating keratoplasties in patients treated with systemic antiviral and immunosuppressive drugs. Method: The authors retrospectively analysed data of 12 patients who underwent penetrating keratoplasty. The average age at onset of the first keratitis preceding surgery was 18 years (between 5 and 40 years). The indication for surgery in 9 cases was to improve vision and in 3 patient to prevent corneal perforation. Nine patients were given both acyclovir and mycophenolate mofetil, as anti-viral agent and immunosuppressive treatment, respectively. Two patients were treated with anti-viral agent only while one patient received no systemic therapy. The average follow-up time was 53.1 months (between 16 and 84 months). Results: Of the 9 patients who underwent surgery for improving vision, 8 patients had transparent grafts during follow up without vascularization. All eight patients had been treated with acyclovir and mycophenolate mofetil. In one patient who had no systemic treatment recurrence and graft rejection was observed. Only one of the surgeries performed in acute stage of inflammation resulted in a properly healed transparent graft without recurrence and rejection. In this patient acyclivir and mycophenolate mofetil therapy had been given previously. In two cases the preventive - full or partial - systemic treatment had no effect. The visual acuity improved in all cases. In three patients visual acuity was influenced by some other factors as well. Conclusions: The systemic acyclovir and mycophenolat mofetil therapy is fairly successful in perforating keratoplasty due to herpes simplex infection. Acyclovir decreases the risk of recurrence, while mycophenolate mofetil may prevent graft rejection. The timing of surgery is decisive; it leads to better results when performed in a scarred, noninflammatory state. Orv. Hetil., 2013, 154(52), 2065-2070.",
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AB - Introduction: Keratitis due to herpes simplex infection is a common cause of corneal damage resulting in impaired vision. Aim: The aim of this study was to assess the outcome of penetrating keratoplasties in patients treated with systemic antiviral and immunosuppressive drugs. Method: The authors retrospectively analysed data of 12 patients who underwent penetrating keratoplasty. The average age at onset of the first keratitis preceding surgery was 18 years (between 5 and 40 years). The indication for surgery in 9 cases was to improve vision and in 3 patient to prevent corneal perforation. Nine patients were given both acyclovir and mycophenolate mofetil, as anti-viral agent and immunosuppressive treatment, respectively. Two patients were treated with anti-viral agent only while one patient received no systemic therapy. The average follow-up time was 53.1 months (between 16 and 84 months). Results: Of the 9 patients who underwent surgery for improving vision, 8 patients had transparent grafts during follow up without vascularization. All eight patients had been treated with acyclovir and mycophenolate mofetil. In one patient who had no systemic treatment recurrence and graft rejection was observed. Only one of the surgeries performed in acute stage of inflammation resulted in a properly healed transparent graft without recurrence and rejection. In this patient acyclivir and mycophenolate mofetil therapy had been given previously. In two cases the preventive - full or partial - systemic treatment had no effect. The visual acuity improved in all cases. In three patients visual acuity was influenced by some other factors as well. Conclusions: The systemic acyclovir and mycophenolat mofetil therapy is fairly successful in perforating keratoplasty due to herpes simplex infection. Acyclovir decreases the risk of recurrence, while mycophenolate mofetil may prevent graft rejection. The timing of surgery is decisive; it leads to better results when performed in a scarred, noninflammatory state. Orv. Hetil., 2013, 154(52), 2065-2070.

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